Systematic Spatial Bias in DNA Microarray Hybridization Is Caused by Probe Spot Position-Dependent Variability in Lateral Diffusion

Systematic Spatial Bias in DNA Microarray Hybridization Is Caused by Probe Spot Position-Dependent Variability in Lateral Diffusion

Background The hybridization of nucleic acid targets with surface-immobilized probes is a widely used assay for the parallel detection of multiple targets in medical and biological research. Despite its widespread application, DNA microarray technology still suffers from several biases and lack o...

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Bibliographic Details
Main Authors: Steger, Doris, Berry, David, Haider, Susanne, Horn, Matthias, Wagner, Michael, Stocker, Roman, Loy, Alexander
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2011
Online Access:http://hdl.handle.net/1721.1/66151
https://orcid.org/0000-0002-3199-0508

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http://hdl.handle.net/1721.1/66151
https://orcid.org/0000-0002-3199-0508

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