A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a co...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Public Library of Science
2011
|
| Online Access: | http://hdl.handle.net/1721.1/66215 https://orcid.org/0000-0001-5096-1932 https://orcid.org/0000-0002-8017-809X https://orcid.org/0000-0002-3715-923X |
| Summary: | The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to
interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE
Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional
elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with
their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have
been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made
available through a freely accessible database. Here we provide an overview of the project and the resources it is generating
and illustrate the application of ENCODE data to interpret the human genome. |
|---|