A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a co...
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2011
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| Online Access: | http://hdl.handle.net/1721.1/66215 https://orcid.org/0000-0001-5096-1932 https://orcid.org/0000-0002-8017-809X https://orcid.org/0000-0002-3715-923X |
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| author | Bernstein, Bradley E. Epstein, Charles B. Shoresh, Noam Ernst, Jason Mikkelsen, Tarjei Sigurd Kheradpour, Pouya Zhang, Xiaolan Wang, Li Issner, Robbyn Coyne, Michael J. Durham, Timothy Ku, Manching Truong, Thanh Ward, Lucas D. Altshuler, Robert Charles Lin, Michael F. Kellis, Manolis ENCODE Project Consortium |
| author2 | Broad Institute of MIT and Harvard |
| author_facet | Broad Institute of MIT and Harvard Bernstein, Bradley E. Epstein, Charles B. Shoresh, Noam Ernst, Jason Mikkelsen, Tarjei Sigurd Kheradpour, Pouya Zhang, Xiaolan Wang, Li Issner, Robbyn Coyne, Michael J. Durham, Timothy Ku, Manching Truong, Thanh Ward, Lucas D. Altshuler, Robert Charles Lin, Michael F. Kellis, Manolis ENCODE Project Consortium |
| author_sort | Bernstein, Bradley E. |
| collection | MIT |
| description | The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to
interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE
Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional
elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with
their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have
been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made
available through a freely accessible database. Here we provide an overview of the project and the resources it is generating
and illustrate the application of ENCODE data to interpret the human genome. |
| first_indexed | 2024-09-23T09:55:29Z |
| format | Article |
| id | mit-1721.1/66215 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:55:29Z |
| publishDate | 2011 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/662152022-09-30T17:44:39Z A User's Guide to the Encyclopedia of DNA Elements (ENCODE) Bernstein, Bradley E. Epstein, Charles B. Shoresh, Noam Ernst, Jason Mikkelsen, Tarjei Sigurd Kheradpour, Pouya Zhang, Xiaolan Wang, Li Issner, Robbyn Coyne, Michael J. Durham, Timothy Ku, Manching Truong, Thanh Ward, Lucas D. Altshuler, Robert Charles Lin, Michael F. Kellis, Manolis ENCODE Project Consortium Broad Institute of MIT and Harvard Lincoln Laboratory Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Physics Kellis, Manolis Epstein, Charles B. Bernstein, Bradley E. Shoresh, Noam Ernst, Jason Mikkelsen, Tarjei Sigurd Kheradpour, Pouya Zhang, Xiaolan Wang, Li Issner, Robbyn Coyne, Michael J. Durham, Timothy Ku, Manching Truong, Thanh Ward, Lucas D. Altshuler, Robert Charles Lin, Michael F. Kellis, Manolis ENCODE Project Consortium The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome. National Human Genome Research Institute (U.S.) National Institutes of Health (U.S.) 2011-10-12T14:02:52Z 2011-10-12T14:02:52Z 2011-04 2010-09 Article http://purl.org/eprint/type/JournalArticle 1544-9173 1545-7885 http://hdl.handle.net/1721.1/66215 The ENCODE Project Consortium (2011) "A User’s Guide to the Encyclopedia of DNA Elements (ENCODE)." PLoS Biology 9(4): e1001046. https://orcid.org/0000-0001-5096-1932 https://orcid.org/0000-0002-8017-809X https://orcid.org/0000-0002-3715-923X en_US http://dx.doi.org/10.1371/journal.pbio.1001046 PLoS Biology Creative Commons Attribution http://creativecommons.org/licenses/by/2.5/ application/pdf Public Library of Science PLoS |
| spellingShingle | Bernstein, Bradley E. Epstein, Charles B. Shoresh, Noam Ernst, Jason Mikkelsen, Tarjei Sigurd Kheradpour, Pouya Zhang, Xiaolan Wang, Li Issner, Robbyn Coyne, Michael J. Durham, Timothy Ku, Manching Truong, Thanh Ward, Lucas D. Altshuler, Robert Charles Lin, Michael F. Kellis, Manolis ENCODE Project Consortium A User's Guide to the Encyclopedia of DNA Elements (ENCODE) |
| title | A User's Guide to the Encyclopedia of DNA Elements (ENCODE) |
| title_full | A User's Guide to the Encyclopedia of DNA Elements (ENCODE) |
| title_fullStr | A User's Guide to the Encyclopedia of DNA Elements (ENCODE) |
| title_full_unstemmed | A User's Guide to the Encyclopedia of DNA Elements (ENCODE) |
| title_short | A User's Guide to the Encyclopedia of DNA Elements (ENCODE) |
| title_sort | user s guide to the encyclopedia of dna elements encode |
| url | http://hdl.handle.net/1721.1/66215 https://orcid.org/0000-0001-5096-1932 https://orcid.org/0000-0002-8017-809X https://orcid.org/0000-0002-3715-923X |
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