DNA demethylation by DNA repair
Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the exi...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier Science Publishers
2011
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| Online Access: | http://hdl.handle.net/1721.1/66231 https://orcid.org/0000-0003-2280-1522 |
| _version_ | 1826195336183414784 |
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| author | Gehring, Mary Reik, Wolf Henikoff, Steven |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Gehring, Mary Reik, Wolf Henikoff, Steven |
| author_sort | Gehring, Mary |
| collection | MIT |
| description | Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achieving it remain murky and mammals lack counterparts to the plant demethylases. Several intriguing experiments have indicated, but not conclusively proven, that DNA repair is also a plausible mechanism for animal demethylation. Here, we examine what is known from flowering plants about the pathways and function of enzymatic demethylation and discuss possible mechanisms whereby DNA repair might also underlie global demethylation in mammals. |
| first_indexed | 2024-09-23T10:11:06Z |
| format | Article |
| id | mit-1721.1/66231 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:11:06Z |
| publishDate | 2011 |
| publisher | Elsevier Science Publishers |
| record_format | dspace |
| spelling | mit-1721.1/662312022-09-30T19:26:19Z DNA demethylation by DNA repair Gehring, Mary Reik, Wolf Henikoff, Steven Massachusetts Institute of Technology. Department of Biology Gehring, Mary Gehring, Mary Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achieving it remain murky and mammals lack counterparts to the plant demethylases. Several intriguing experiments have indicated, but not conclusively proven, that DNA repair is also a plausible mechanism for animal demethylation. Here, we examine what is known from flowering plants about the pathways and function of enzymatic demethylation and discuss possible mechanisms whereby DNA repair might also underlie global demethylation in mammals. Life Sciences Research Foundation (Fellow) European Union (EU NoE The Epigenome) Biotechnology and Biological Sciences Research Council (Great Britain) Medical Research Council (Great Britain) 2011-10-13T13:30:20Z 2011-10-13T13:30:20Z 2009-02 Article http://purl.org/eprint/type/JournalArticle 0168-9525 http://hdl.handle.net/1721.1/66231 Gehring, Mary, Wolf Reik, and Steven Henikoff. “DNA demethylation by DNA repair.” Trends in Genetics 25 (2009): 82-90. https://orcid.org/0000-0003-2280-1522 en_US http://dx.doi.org/10.1016/j.tig.2008.12.001 Trends in Genetics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Science Publishers Gehring |
| spellingShingle | Gehring, Mary Reik, Wolf Henikoff, Steven DNA demethylation by DNA repair |
| title | DNA demethylation by DNA repair |
| title_full | DNA demethylation by DNA repair |
| title_fullStr | DNA demethylation by DNA repair |
| title_full_unstemmed | DNA demethylation by DNA repair |
| title_short | DNA demethylation by DNA repair |
| title_sort | dna demethylation by dna repair |
| url | http://hdl.handle.net/1721.1/66231 https://orcid.org/0000-0003-2280-1522 |
| work_keys_str_mv | AT gehringmary dnademethylationbydnarepair AT reikwolf dnademethylationbydnarepair AT henikoffsteven dnademethylationbydnarepair |