A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans
The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging in Caenorhabditis elegans, intestinal tissue deterioration and the increased intestinal proliferation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2011
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| Online Access: | http://hdl.handle.net/1721.1/66261 https://orcid.org/0000-0002-4109-5152 |
| _version_ | 1826210205966270464 |
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| author | Youngman, Matthew J. Rogers, Zoe N. Kim, Dennis H. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Youngman, Matthew J. Rogers, Zoe N. Kim, Dennis H. |
| author_sort | Youngman, Matthew J. |
| collection | MIT |
| description | The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging in Caenorhabditis elegans, intestinal tissue deterioration and the increased intestinal proliferation of bacteria are observed, but how innate immunity changes during C. elegans aging has not been defined. Here we show that C. elegans exhibits increased susceptibility to bacterial infection with age, and we establish that aging is associated with a decline in the activity of the conserved PMK-1 p38 mitogen-activated protein kinase pathway, which regulates innate immunity in C. elegans. Our data define the phenomenon of innate immunosenescence in C. elegans in terms of the age-dependent dynamics of the PMK-1 innate immune signaling pathway, and they suggest that a cycle of intestinal tissue aging, immunosenescence, and bacterial proliferation leads to death in aging C. elegans. |
| first_indexed | 2024-09-23T14:46:08Z |
| format | Article |
| id | mit-1721.1/66261 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:46:08Z |
| publishDate | 2011 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/662612022-10-01T22:19:36Z A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans Youngman, Matthew J. Rogers, Zoe N. Kim, Dennis H. Massachusetts Institute of Technology. Department of Biology Kim, Dennis H. Kim, Dennis H. Youngman, Matthew J. Rogers, Zoe N. The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging in Caenorhabditis elegans, intestinal tissue deterioration and the increased intestinal proliferation of bacteria are observed, but how innate immunity changes during C. elegans aging has not been defined. Here we show that C. elegans exhibits increased susceptibility to bacterial infection with age, and we establish that aging is associated with a decline in the activity of the conserved PMK-1 p38 mitogen-activated protein kinase pathway, which regulates innate immunity in C. elegans. Our data define the phenomenon of innate immunosenescence in C. elegans in terms of the age-dependent dynamics of the PMK-1 innate immune signaling pathway, and they suggest that a cycle of intestinal tissue aging, immunosenescence, and bacterial proliferation leads to death in aging C. elegans. Amgen Scholars Program Cancer Research Institute (New York, N.Y.) (Irvington Institute Fellowship Program) Ellison Medical Foundation (New Scholar Award) Burroughs Wellcome Fund (Career Award in the Biomedical Sciences) National Institutes of Health (U.S.) (NIH grant R01-GM084477) Robert A. Swanson Fund 2011-10-14T19:34:09Z 2011-10-14T19:34:09Z 2011-05 2010-12 Article http://purl.org/eprint/type/JournalArticle 1553-7404 1553-7390 http://hdl.handle.net/1721.1/66261 Youngman, Matthew J., Zoë N. Rogers, and Dennis H. Kim. “A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans.” Ed. Stuart K. Kim. PLoS Genetics 7 (2011): e1002082. https://orcid.org/0000-0002-4109-5152 en_US http://dx.doi.org/10.1371/journal.pgen.1002082 PLoS Genetics Creative Commons Attribution http://creativecommons.org/licenses/by/2.5/ application/pdf Public Library of Science PLoS |
| spellingShingle | Youngman, Matthew J. Rogers, Zoe N. Kim, Dennis H. A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans |
| title | A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans |
| title_full | A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans |
| title_fullStr | A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans |
| title_full_unstemmed | A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans |
| title_short | A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans |
| title_sort | decline in p38 mapk signaling underlies immunosenescence in caenorhabditis elegans |
| url | http://hdl.handle.net/1721.1/66261 https://orcid.org/0000-0002-4109-5152 |
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