Pulsation and stabilization: Contractile forces that underlie morphogenesis
Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets. Morphogenetic changes at the cell and tissue level require that cells generate forces and that these forces are transmitted between the...
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| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2011
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| Online Access: | http://hdl.handle.net/1721.1/66552 https://orcid.org/0000-0001-8060-2607 |
| _version_ | 1826203947266736128 |
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| author | Martin, Adam C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Martin, Adam C |
| author_sort | Martin, Adam C |
| collection | MIT |
| description | Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets. Morphogenetic changes at the cell and tissue level require that cells generate forces and that these forces are transmitted between the cells of a coherent tissue. Contractile forces generated by the actin–myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Recent studies that have combined live imaging with computational and biophysical approaches have provided new insights into how contractile forces are generated and coordinated between cells and tissues. In this review, we discuss our current understanding of the mechanical forces that shape cells, tissues, and embryos, emphasizing the different modes of actomyosin contraction that generate various temporal and spatial patterns of force generation. |
| first_indexed | 2024-09-23T12:45:57Z |
| format | Article |
| id | mit-1721.1/66552 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:45:57Z |
| publishDate | 2011 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/665522022-10-01T10:58:04Z Pulsation and stabilization: Contractile forces that underlie morphogenesis Martin, Adam C Massachusetts Institute of Technology. Department of Biology Martin, Adam C. Martin, Adam C. Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets. Morphogenetic changes at the cell and tissue level require that cells generate forces and that these forces are transmitted between the cells of a coherent tissue. Contractile forces generated by the actin–myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Recent studies that have combined live imaging with computational and biophysical approaches have provided new insights into how contractile forces are generated and coordinated between cells and tissues. In this review, we discuss our current understanding of the mechanical forces that shape cells, tissues, and embryos, emphasizing the different modes of actomyosin contraction that generate various temporal and spatial patterns of force generation. American Cancer Society (grant PF-06- 143-01-DDC) 2011-10-24T16:12:26Z 2011-10-24T16:12:26Z 2010-05 2009-10 Article http://purl.org/eprint/type/JournalArticle 1095-564X 0012-1606 http://hdl.handle.net/1721.1/66552 Martin, Adam C. “Pulsation and stabilization: Contractile forces that underlie morphogenesis.” Developmental Biology 341 (2010): 114-125. https://orcid.org/0000-0001-8060-2607 en_US http://dx.doi.org/10.1016/j.ydbio.2009.10.031 Developmental Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier B.V. Martin |
| spellingShingle | Martin, Adam C Pulsation and stabilization: Contractile forces that underlie morphogenesis |
| title | Pulsation and stabilization: Contractile forces that underlie morphogenesis |
| title_full | Pulsation and stabilization: Contractile forces that underlie morphogenesis |
| title_fullStr | Pulsation and stabilization: Contractile forces that underlie morphogenesis |
| title_full_unstemmed | Pulsation and stabilization: Contractile forces that underlie morphogenesis |
| title_short | Pulsation and stabilization: Contractile forces that underlie morphogenesis |
| title_sort | pulsation and stabilization contractile forces that underlie morphogenesis |
| url | http://hdl.handle.net/1721.1/66552 https://orcid.org/0000-0001-8060-2607 |
| work_keys_str_mv | AT martinadamc pulsationandstabilizationcontractileforcesthatunderliemorphogenesis |