Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding
Cytokinesis, the final stage of the cell division cycle, requires the proper placement, assembly and contraction of an actomyosin-based contractile ring. Conserved sets of cytokinesis proteins and pathways have now been identified and characterized functionally. Additionally, fluorescent protein fus...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2011
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| Online Access: | http://hdl.handle.net/1721.1/66558 https://orcid.org/0000-0002-6199-6855 |
| _version_ | 1811090457204097024 |
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| author | Bathe, Mark Chang, Fred |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Bathe, Mark Chang, Fred |
| author_sort | Bathe, Mark |
| collection | MIT |
| description | Cytokinesis, the final stage of the cell division cycle, requires the proper placement, assembly and contraction of an actomyosin-based contractile ring. Conserved sets of cytokinesis proteins and pathways have now been identified and characterized functionally. Additionally, fluorescent protein fusion technology enables quantitative high-resolution imaging of protein dynamics in living cells. For these reasons, the study of cytokinesis is now ripe for quantitative, systems-level approaches. Here, we review our current understanding of the molecular mechanisms of contractile ring dynamics in the model organism Schizosaccharomyces pombe (fission yeast), focusing on recent examples that illustrate a synergistic integration of quantitative experimental data with computational modeling. A picture of a highly dynamic and integrated system consisting of overlapping networks is beginning to emerge, the detailed nature of which remains to be elucidated. |
| first_indexed | 2024-09-23T14:46:28Z |
| format | Article |
| id | mit-1721.1/66558 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:46:28Z |
| publishDate | 2011 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/665582022-10-01T22:22:25Z Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding Bathe, Mark Chang, Fred Massachusetts Institute of Technology. Department of Biological Engineering Bathe, Mark Bathe, Mark Cytokinesis, the final stage of the cell division cycle, requires the proper placement, assembly and contraction of an actomyosin-based contractile ring. Conserved sets of cytokinesis proteins and pathways have now been identified and characterized functionally. Additionally, fluorescent protein fusion technology enables quantitative high-resolution imaging of protein dynamics in living cells. For these reasons, the study of cytokinesis is now ripe for quantitative, systems-level approaches. Here, we review our current understanding of the molecular mechanisms of contractile ring dynamics in the model organism Schizosaccharomyces pombe (fission yeast), focusing on recent examples that illustrate a synergistic integration of quantitative experimental data with computational modeling. A picture of a highly dynamic and integrated system consisting of overlapping networks is beginning to emerge, the detailed nature of which remains to be elucidated. National Institutes of Health (U.S.) (NIH grant GM05683) Massachusetts Institute of Technology (Samuel A. Goldblith Career Development Professorship) Massachusetts Institute of Technology (Faculty startup funds) 2011-10-24T19:36:02Z 2011-10-24T19:36:02Z 2010-01 Article http://purl.org/eprint/type/JournalArticle 0966-842X 1878-4380 http://hdl.handle.net/1721.1/66558 Bathe, Mark, and Fred Chang. “Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding.” Trends in Microbiology 18 (2010): 38-45. https://orcid.org/0000-0002-6199-6855 en_US http://dx.doi.org/10.1016/j.tim.2009.10.002 Trends in Microbiology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier B.V. PubMed Central |
| spellingShingle | Bathe, Mark Chang, Fred Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding |
| title | Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding |
| title_full | Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding |
| title_fullStr | Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding |
| title_full_unstemmed | Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding |
| title_short | Cytokinesis and the contractile ring in fission yeast: towards a systems-level understanding |
| title_sort | cytokinesis and the contractile ring in fission yeast towards a systems level understanding |
| url | http://hdl.handle.net/1721.1/66558 https://orcid.org/0000-0002-6199-6855 |
| work_keys_str_mv | AT bathemark cytokinesisandthecontractileringinfissionyeasttowardsasystemslevelunderstanding AT changfred cytokinesisandthecontractileringinfissionyeasttowardsasystemslevelunderstanding |