Reconstructing the Evolution of Vertebrate Sex Chromosomes
http://symposium.cshlp.org/content/74/345.full.pdf+html
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Cold Spring Harbor Laboratory
2011
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| Online Access: | http://hdl.handle.net/1721.1/66577 https://orcid.org/0000-0001-9920-3411 |
| _version_ | 1811080499932692480 |
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| author | Bellott, Daniel W. Page, David C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bellott, Daniel W. Page, David C |
| author_sort | Bellott, Daniel W. |
| collection | MIT |
| description | http://symposium.cshlp.org/content/74/345.full.pdf+html |
| first_indexed | 2024-09-23T11:32:38Z |
| format | Article |
| id | mit-1721.1/66577 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:32:38Z |
| publishDate | 2011 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | dspace |
| spelling | mit-1721.1/665772022-09-27T20:12:24Z Reconstructing the Evolution of Vertebrate Sex Chromosomes Bellott, Daniel W. Page, David C Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Page, David C. Page, David C. Bellott, Daniel W. http://symposium.cshlp.org/content/74/345.full.pdf+html Sex chromosomes and their evolution have captivated researchers since their discovery. For more than 100 years, the dominant model of sex chromosome evolution has held that differentiated sex chromosomes, such as the X and Y chromosomes of mammals or the Z and W chromosomes of birds, evolved from ordinary autosomes, primarily through the degeneration of the sex-specific Y or W chromosome. At the same time, the sex chromosomes shared between sexes, the X and Z chromosomes, are expected to remain essentially untouched. This model was based on limited cytogenetic and genetic data. Only in the last decade, with the advent of genomics, has the complete sequence of any sex chromosome pair become available. High-quality finished sequences of the human and chimpanzee Y chromosomes, as well as the human X chromosome, have revealed sequence features unanticipated by the traditional model of sex chromosome evolution. Large, highly identical, tandem and inverted arrays of testis-expressed genes are major sources of innovation in gene content on sex-specific chromosomes as well as sex-shared chromosomes. Accounting for the emergence of these ampliconic structures presents a challenge for future studies of sex chromosome evolution. National Institutes of Health (U.S.) Howard Hughes Medical Institute 2011-10-25T15:48:06Z 2011-10-25T15:48:06Z 2010-01 Article http://purl.org/eprint/type/ConferencePaper 0091-7451 http://hdl.handle.net/1721.1/66577 Bellott, D.W. and D.C. Page."Reconstructing the Evolution of Vertebrate Sex Chromosomes." Cold Spring Harbor Symposia on Quantitative Biology, 2009. 74: 345-353. https://orcid.org/0000-0001-9920-3411 en_US http://dx.doi.org/10.1101/sqb.2009.74.048 Cold Spring Harbor Symposia on Quantitative Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Cold Spring Harbor Laboratory Page |
| spellingShingle | Bellott, Daniel W. Page, David C Reconstructing the Evolution of Vertebrate Sex Chromosomes |
| title | Reconstructing the Evolution of Vertebrate Sex Chromosomes |
| title_full | Reconstructing the Evolution of Vertebrate Sex Chromosomes |
| title_fullStr | Reconstructing the Evolution of Vertebrate Sex Chromosomes |
| title_full_unstemmed | Reconstructing the Evolution of Vertebrate Sex Chromosomes |
| title_short | Reconstructing the Evolution of Vertebrate Sex Chromosomes |
| title_sort | reconstructing the evolution of vertebrate sex chromosomes |
| url | http://hdl.handle.net/1721.1/66577 https://orcid.org/0000-0001-9920-3411 |
| work_keys_str_mv | AT bellottdanielw reconstructingtheevolutionofvertebratesexchromosomes AT pagedavidc reconstructingtheevolutionofvertebratesexchromosomes |