Can the meniscus affect the nature of a chondrocyte?
It is well understood that proper joint kinematics and loading are important factors in maintaining the health of the articular cartilage of the knee. This state of normal, physiologic loading facilitates a balance between anabolic and catabolic processes resulting in low level, homeostatic cartilag...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier Ltd.
2011
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| Online Access: | http://hdl.handle.net/1721.1/66581 https://orcid.org/0000-0002-4942-3456 |
| _version_ | 1826217533951180800 |
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| author | Vanderploeg, Eric J. Grodzinsky, Alan J. |
| author2 | Massachusetts Institute of Technology. Center for Biomedical Engineering |
| author_facet | Massachusetts Institute of Technology. Center for Biomedical Engineering Vanderploeg, Eric J. Grodzinsky, Alan J. |
| author_sort | Vanderploeg, Eric J. |
| collection | MIT |
| description | It is well understood that proper joint kinematics and loading are important factors in maintaining the health of the articular cartilage of the knee. This state of normal, physiologic loading facilitates a balance between anabolic and catabolic processes resulting in low level, homeostatic cartilage matrix turn-over and remodeling. In this way articular cartilage can function throughout an entire lifetime without loss of its load bearing or lubricating characteristics. However, situations that dramatically alter knee joint biomechanics, such as chronic disuse or overuse[superscript 1-4], anterior cruciate ligament (ACL) injury[superscript 5,6], or damage to the fibrocartilaginous menisci[superscript 7-11], can result in progressive cartilage degradation and strongly correlate with the onset of osteoarthritis (OA). |
| first_indexed | 2024-09-23T17:05:11Z |
| format | Article |
| id | mit-1721.1/66581 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:05:11Z |
| publishDate | 2011 |
| publisher | Elsevier Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/665812022-10-03T10:17:54Z Can the meniscus affect the nature of a chondrocyte? Vanderploeg, Eric J. Grodzinsky, Alan J. Massachusetts Institute of Technology. Center for Biomedical Engineering Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Mechanical Engineering Grodzinsky, Alan J. Vanderploeg, Eric J. Grodzinsky, Alan J. It is well understood that proper joint kinematics and loading are important factors in maintaining the health of the articular cartilage of the knee. This state of normal, physiologic loading facilitates a balance between anabolic and catabolic processes resulting in low level, homeostatic cartilage matrix turn-over and remodeling. In this way articular cartilage can function throughout an entire lifetime without loss of its load bearing or lubricating characteristics. However, situations that dramatically alter knee joint biomechanics, such as chronic disuse or overuse[superscript 1-4], anterior cruciate ligament (ACL) injury[superscript 5,6], or damage to the fibrocartilaginous menisci[superscript 7-11], can result in progressive cartilage degradation and strongly correlate with the onset of osteoarthritis (OA). 2011-10-26T16:28:34Z 2011-10-26T16:28:34Z 2009-05 Article http://purl.org/eprint/type/JournalArticle 1063-4584 http://hdl.handle.net/1721.1/66581 Vanderploeg, E.J., and A.J. Grodzinsky. “Can the meniscus affect the nature of a chondrocyte?” Osteoarthritis and Cartilage 17 (2009): 969-970. Web. 26 Oct. 2011. © 2011 Elsevier Ltd. https://orcid.org/0000-0002-4942-3456 en_US http://dx.doi.org/10.1016/j.joca.2009.05.007 Osteoarthritis and Cartilage Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier Ltd. PubMed Central |
| spellingShingle | Vanderploeg, Eric J. Grodzinsky, Alan J. Can the meniscus affect the nature of a chondrocyte? |
| title | Can the meniscus affect the nature of a chondrocyte? |
| title_full | Can the meniscus affect the nature of a chondrocyte? |
| title_fullStr | Can the meniscus affect the nature of a chondrocyte? |
| title_full_unstemmed | Can the meniscus affect the nature of a chondrocyte? |
| title_short | Can the meniscus affect the nature of a chondrocyte? |
| title_sort | can the meniscus affect the nature of a chondrocyte |
| url | http://hdl.handle.net/1721.1/66581 https://orcid.org/0000-0002-4942-3456 |
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