IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage

IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage

Objective To determine changes in chondrocyte transcription of a range of anabolic, catabolic and signaling genes following simultaneous treatment of cartilage with Insulin-like growth factor-1 (IGF-1) and ramp-and-hold mechanical compression, and compare with effects on biosynthesis. Methods...

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Bibliographic Details
Main Authors: Grodzinsky, Alan J., Wheeler, Cameron A., Jafarzadeh, Seyed R., Rocke, David M.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier Ltd. 2011
Online Access:http://hdl.handle.net/1721.1/66590
https://orcid.org/0000-0002-4942-3456

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