Relevance of collagen piezoelectricity to "Wolff's Law": A critical review
According to “Wolff's Law”, bone is deposited and reinforced at areas of greatest stress. From a clinical perspective, this “law” is supported by the strong association between bone density and physical activity. From a mechanistic standpoint, however, the law presents a challenge to scientists...
| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | en_US |
| Publicado em: |
Elsevier Ltd.
2011
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| Acesso em linha: | http://hdl.handle.net/1721.1/66591 https://orcid.org/0000-0002-4942-3456 |
| _version_ | 1826214297757286400 |
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| author | Ahn, Andrew C. Grodzinsky, Alan J. |
| author2 | Massachusetts Institute of Technology. Center for Biomedical Engineering |
| author_facet | Massachusetts Institute of Technology. Center for Biomedical Engineering Ahn, Andrew C. Grodzinsky, Alan J. |
| author_sort | Ahn, Andrew C. |
| collection | MIT |
| description | According to “Wolff's Law”, bone is deposited and reinforced at areas of greatest stress. From a clinical perspective, this “law” is supported by the strong association between bone density and physical activity. From a mechanistic standpoint, however, the law presents a challenge to scientists seeking to understand how osteocytes and osteoblasts sense the mechanical load. In the 1960s, collagen piezoelectricity was invoked as a potential mechanism by which osteocytes could detect areas of greater stress but piezoelectricity diminished in importance as more compelling mechanisms, such as streaming potential, were identified. In addition, accumulating evidence for the role of fluid-related shear stress in osteocyte's mechanosensory function has made piezoelectricity seemingly more obsolete in bone physiology. This review critically evaluates the role of collagen piezoelectricity (if any) in Wolff's Law—specifically, the evidence regarding its involvement in strain-generated potentials, existing alternate mechanisms, the present understanding of bone mechanosensation, and whether piezoelectricity serves an influential role within the context of this newly proposed mechanism. In addition to reviewing the literature, this review generates several hypotheses and proposes future research to fully address the relevance of piezoelectricity in bone physiology. |
| first_indexed | 2024-09-23T16:03:19Z |
| format | Article |
| id | mit-1721.1/66591 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:03:19Z |
| publishDate | 2011 |
| publisher | Elsevier Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/665912022-10-02T06:01:40Z Relevance of collagen piezoelectricity to "Wolff's Law": A critical review Ahn, Andrew C. Grodzinsky, Alan J. Massachusetts Institute of Technology. Center for Biomedical Engineering Massachusetts Institute of Technology. Department of Biological Engineering Grodzinsky, Alan J. Grodzinsky, Alan J. Ahn, Andrew C. According to “Wolff's Law”, bone is deposited and reinforced at areas of greatest stress. From a clinical perspective, this “law” is supported by the strong association between bone density and physical activity. From a mechanistic standpoint, however, the law presents a challenge to scientists seeking to understand how osteocytes and osteoblasts sense the mechanical load. In the 1960s, collagen piezoelectricity was invoked as a potential mechanism by which osteocytes could detect areas of greater stress but piezoelectricity diminished in importance as more compelling mechanisms, such as streaming potential, were identified. In addition, accumulating evidence for the role of fluid-related shear stress in osteocyte's mechanosensory function has made piezoelectricity seemingly more obsolete in bone physiology. This review critically evaluates the role of collagen piezoelectricity (if any) in Wolff's Law—specifically, the evidence regarding its involvement in strain-generated potentials, existing alternate mechanisms, the present understanding of bone mechanosensation, and whether piezoelectricity serves an influential role within the context of this newly proposed mechanism. In addition to reviewing the literature, this review generates several hypotheses and proposes future research to fully address the relevance of piezoelectricity in bone physiology. National Center for Complementary and Alternative Medicine (U.S.) (grant K23-AT003238) 2011-10-26T18:07:16Z 2011-10-26T18:07:16Z 2009-03 2009-02 Article http://purl.org/eprint/type/JournalArticle 1350-4533 http://hdl.handle.net/1721.1/66591 Ahn, Andrew C., and Alan J. Grodzinsky. “Relevance of collagen piezoelectricity to ‘Wolff’s Law’: A critical review.” Medical Engineering & Physics 31 (2009): 733-741. Web. 26 Oct. 2011. © 2009 Elsevier Ltd. https://orcid.org/0000-0002-4942-3456 en_US http://dx.doi.org/10.1016/j.medengphy.2009.02.006 Medical Engineering and Physics Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier Ltd. PubMed Central |
| spellingShingle | Ahn, Andrew C. Grodzinsky, Alan J. Relevance of collagen piezoelectricity to "Wolff's Law": A critical review |
| title | Relevance of collagen piezoelectricity to "Wolff's Law": A critical review |
| title_full | Relevance of collagen piezoelectricity to "Wolff's Law": A critical review |
| title_fullStr | Relevance of collagen piezoelectricity to "Wolff's Law": A critical review |
| title_full_unstemmed | Relevance of collagen piezoelectricity to "Wolff's Law": A critical review |
| title_short | Relevance of collagen piezoelectricity to "Wolff's Law": A critical review |
| title_sort | relevance of collagen piezoelectricity to wolff s law a critical review |
| url | http://hdl.handle.net/1721.1/66591 https://orcid.org/0000-0002-4942-3456 |
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