Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift
Refer to Web version on PubMed Central for supplementary material.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science
2011
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| Online Access: | http://hdl.handle.net/1721.1/67038 https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0002-2085-7840 |
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| author | Hensley, Scott E. Das, Suman R. Bailey, Adam L. Schmidt, Loren M. Hickman, Heather D. Bennink, Jack R. Yewdell, Jonathan W. Jayaraman, Akila Viswanathan, Karthik Raman, Rahul Sasisekharan, Ram |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Hensley, Scott E. Das, Suman R. Bailey, Adam L. Schmidt, Loren M. Hickman, Heather D. Bennink, Jack R. Yewdell, Jonathan W. Jayaraman, Akila Viswanathan, Karthik Raman, Rahul Sasisekharan, Ram |
| author_sort | Hensley, Scott E. |
| collection | MIT |
| description | Refer to Web version on PubMed Central for supplementary material. |
| first_indexed | 2024-09-23T11:45:12Z |
| format | Article |
| id | mit-1721.1/67038 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:45:12Z |
| publishDate | 2011 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | mit-1721.1/670382022-10-01T05:44:02Z Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift Hensley, Scott E. Das, Suman R. Bailey, Adam L. Schmidt, Loren M. Hickman, Heather D. Bennink, Jack R. Yewdell, Jonathan W. Jayaraman, Akila Viswanathan, Karthik Raman, Rahul Sasisekharan, Ram Harvard University--MIT Division of Health Sciences and Technology Koch Institute for Integrative Cancer Research at MIT Sasisekharan, Ram Jayaraman, Akila Viswanathan, Karthik Raman, Rahul Sasisekharan, Ram Refer to Web version on PubMed Central for supplementary material. Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing antibodies selected mutants with single–amino acid hemagglutinin substitutions that increased virus binding to cell surface glycan receptors. Passaging these high-avidity binding mutants in naïve mice, but not immune mice, selected for additional hemagglutinin substitutions that decreased cellular receptor binding avidity. Analyzing a panel of monoclonal antibody hemagglutinin escape mutants revealed a positive correlation between receptor binding avidity and escape from polyclonal antibodies. We propose that in response to variation in neutralizing antibody pressure between individuals, influenza A virus evolves by adjusting receptor binding avidity via amino acid substitutions throughout the hemagglutinin globular domain, many of which simultaneously alter antigenicity. National Institute of Mental Health (U.S.). Division of Intramural Research National Institute of Allergy and Infectious Diseases (U.S.) Singapore-MIT Alliance for Research and Technology National Institute of General Medical Sciences (U.S.) (GM 57073) National Institute of General Medical Sciences (U.S.) (U54GM62116) 2011-11-16T20:02:07Z 2011-11-16T20:02:07Z 2009-10 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/67038 Hensley, S. E. et al. “Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift.” Science 326 (2009): 734-736. Web. 16 Nov. 2011. © 2009 American Association for the Advancement of Science https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0002-2085-7840 en_US http://dx.doi.org/10.1126/science.1178258 Science Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf American Association for the Advancement of Science PubMed Central |
| spellingShingle | Hensley, Scott E. Das, Suman R. Bailey, Adam L. Schmidt, Loren M. Hickman, Heather D. Bennink, Jack R. Yewdell, Jonathan W. Jayaraman, Akila Viswanathan, Karthik Raman, Rahul Sasisekharan, Ram Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift |
| title | Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift |
| title_full | Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift |
| title_fullStr | Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift |
| title_full_unstemmed | Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift |
| title_short | Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift |
| title_sort | hemagglutinin receptor binding avidity drives influenza a virus antigenic drift |
| url | http://hdl.handle.net/1721.1/67038 https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0002-2085-7840 |
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