K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial

K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial

Chronic infectious diseases, such as Helicobacter pylori infection, can promote cancer in a large part through induction of chronic inflammation. Oncogenic K-ras mutation in epithelial cells activates inflammatory pathways, which could compensate for a lack of infectious stimulus. Gastric histopatho...

Full description

Bibliographic Details
Main Authors: Okumura, Tomoyuki, Ericksen, Russell E., Takaishi, Shigeo, Wang, Sophie S. W., Dubeykovskaya, Zinaida, Shibata, Wataru, Betz, Kelly S., Muthupalani, Sureshkumar, Rogers, Arlin B., Fox, James G., Rustgi, Anil K., Wang, Timothy C.
Other Authors: Massachusetts Institute of Technology. Division of Comparative Medicine
Format: Article
Language:en_US
Published: American Association for Cancer Research 2011
Online Access:http://hdl.handle.net/1721.1/67285
https://orcid.org/0000-0001-9307-6116

Similar Items

Similar Items