Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, CagA affects cell shape, increases cell motility, abrogates junctional activi...

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Bibliographic Details
Main Authors: Buti, Ludovico, Spooner, Eric, Van der Veen, Annemarthe G., Rappuoli, Rino, Covacci, Antonello, Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences 2011
Online Access:http://hdl.handle.net/1721.1/67353
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/67353
https://orcid.org/0000-0002-1090-6071

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