Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host
Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, CagA affects cell shape, increases cell motility, abrogates junctional activi...
Main Authors: | Buti, Ludovico, Spooner, Eric, Van der Veen, Annemarthe G., Rappuoli, Rino, Covacci, Antonello, Ploegh, Hidde |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences
2011
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Online Access: | http://hdl.handle.net/1721.1/67353 https://orcid.org/0000-0002-1090-6071 |
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