Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics
A class of peptides from the bombolitin family, not previously identified for nitroaromatic recognition, allows near-infrared fluorescent single-walled carbon nanotubes to transduce specific changes in their conformation. In response to the binding of specific nitroaromatic species, such peptide–nan...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2011
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| Online Access: | http://hdl.handle.net/1721.1/67450 https://orcid.org/0000-0003-2944-808X |
| _version_ | 1826209642136469504 |
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| author | Heller, Daniel A. Pratt, George W. Nair, Nitish Hansborough, Adam J. Boghossian, Ardemis A. Reuel, Nigel Forest Barone, Paul W. Strano, Michael S. Zhang, Jingqing, Ph. D. Massachusetts Institute of Technology |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Heller, Daniel A. Pratt, George W. Nair, Nitish Hansborough, Adam J. Boghossian, Ardemis A. Reuel, Nigel Forest Barone, Paul W. Strano, Michael S. Zhang, Jingqing, Ph. D. Massachusetts Institute of Technology |
| author_sort | Heller, Daniel A. |
| collection | MIT |
| description | A class of peptides from the bombolitin family, not previously identified for nitroaromatic recognition, allows near-infrared fluorescent single-walled carbon nanotubes to transduce specific changes in their conformation. In response to the binding of specific nitroaromatic species, such peptide–nanotube complexes form a virtual “chaperone sensor,” which reports modulation of the peptide secondary structure via changes in single-walled carbon nanotubes, near-infrared photoluminescence. A split-channel microscope constructed to image quantized spectral wavelength shifts in real time, in response to nitroaromatic adsorption, results in the first single-nanotube imaging of solvatochromic events. The described indirect detection mechanism, as well as an additional exciton quenching-based optical nitroaromatic detection method, illustrate that functionalization of the carbon nanotube surface can result in completely unique sites for recognition, resolvable at the single-molecule level. |
| first_indexed | 2024-09-23T14:25:50Z |
| format | Article |
| id | mit-1721.1/67450 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:25:50Z |
| publishDate | 2011 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/674502022-10-01T21:17:45Z Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics Heller, Daniel A. Pratt, George W. Nair, Nitish Hansborough, Adam J. Boghossian, Ardemis A. Reuel, Nigel Forest Barone, Paul W. Strano, Michael S. Zhang, Jingqing, Ph. D. Massachusetts Institute of Technology Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Koch Institute for Integrative Cancer Research at MIT Strano, Michael S. Strano, Michael S. Heller, Daniel A. Pratt, George W. Zhang, Jingqing Nair, Nitish Hansborough, Adam J. Boghossian, Ardemis A. Reuel, Nigel Forest Barone, Paul W. A class of peptides from the bombolitin family, not previously identified for nitroaromatic recognition, allows near-infrared fluorescent single-walled carbon nanotubes to transduce specific changes in their conformation. In response to the binding of specific nitroaromatic species, such peptide–nanotube complexes form a virtual “chaperone sensor,” which reports modulation of the peptide secondary structure via changes in single-walled carbon nanotubes, near-infrared photoluminescence. A split-channel microscope constructed to image quantized spectral wavelength shifts in real time, in response to nitroaromatic adsorption, results in the first single-nanotube imaging of solvatochromic events. The described indirect detection mechanism, as well as an additional exciton quenching-based optical nitroaromatic detection method, illustrate that functionalization of the carbon nanotube surface can result in completely unique sites for recognition, resolvable at the single-molecule level. United States. Army Research Office National Science Foundation (U.S.) Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies Arnold and Mabel Beckman Foundation (Young Investigator Award) 2011-12-06T14:40:43Z 2011-12-06T14:40:43Z 2011-05 2010-05 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/67450 Heller, D. A. et al. “Peptide secondary structure modulates single-walled carbon nanotube fluorescence as a chaperone sensor for nitroaromatics.” Proceedings of the National Academy of Sciences 108.21 (2011): 8544-8549. https://orcid.org/0000-0003-2944-808X en_US http://dx.doi.org/10.1073/pnas.1005512108 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Heller, Daniel A. Pratt, George W. Nair, Nitish Hansborough, Adam J. Boghossian, Ardemis A. Reuel, Nigel Forest Barone, Paul W. Strano, Michael S. Zhang, Jingqing, Ph. D. Massachusetts Institute of Technology Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics |
| title | Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics |
| title_full | Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics |
| title_fullStr | Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics |
| title_full_unstemmed | Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics |
| title_short | Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics |
| title_sort | peptide secondary structure modulates single walled carbon nanotube fluorescence as a chaperone sensor for nitroaromatics |
| url | http://hdl.handle.net/1721.1/67450 https://orcid.org/0000-0003-2944-808X |
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