Selective Killing of K-ras Mutant Cancer Cells by Novel Small Molecule Inducers of Oxidative Stress

Selective Killing of K-ras Mutant Cancer Cells by Novel Small Molecule Inducers of Oxidative Stress

Activating K-RAS mutations are the most frequent oncogenic mutations in human cancer. Numerous downstream signaling pathways have been shown to be deregulated by oncogenic K-ras. However, to date there are still no effective targeted therapies for this genetically defined subset of patients. Here we...

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Bibliographic Details
Main Authors: Shaw, Alice, Winslow, Monte Meier, Magendantz, Margaret, Ouyang, Chensi, Dowdle, James, Subramanian, Aravind, Lewis, Timothy A., Maglathin, Rebecca L., Tolliday, Nicola, Jacks, Tyler E
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2011
Online Access:http://hdl.handle.net/1721.1/67456
https://orcid.org/0000-0001-5785-8911

Internet

http://hdl.handle.net/1721.1/67456
https://orcid.org/0000-0001-5785-8911

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