The Aging-Associated Enzyme CLK-1 is a Member of the Carboxylate-Bridged Diiron Family of Proteins
The aging-associated enzyme CLK-1 is proposed to be a member of the carboxylate-bridged diiron family of proteins. To evaluate this hypothesis and characterize the protein, we expressed soluble mouse CLK-1 (MCLK1) in Escherichia coli as a heterologous host. Using Mossbauer and EPR spectroscopy, we e...
Main Authors: | Behan, Rachel K., Lippard, Stephen J. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society
2011
|
Online Access: | http://hdl.handle.net/1721.1/67722 https://orcid.org/0000-0002-2693-4982 |
Similar Items
-
Evolution of strategies to prepare synthetic mimics of carboxylate-bridged diiron protein active sites
by: Do, Loi Hung, et al.
Published: (2017) -
Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites
by: Li, Yang, et al.
Published: (2013) -
Triptycene-Based, Carboxylate-Bridged Biomimetic Diiron(II) Complexes
by: Li, Yang, et al.
Published: (2015) -
Carboxylate as the Protonation Site in (Peroxo)diiron(III) Model Complexes of Soluble Methane Monooxygenase and Related Diiron Proteins
by: Do, Loi Hung, et al.
Published: (2011) -
Toward Functional Carboxylate-Bridged Diiron Protein Mimics: Achieving Stability and Conformational Flexibility Using a Macrocylic Ligand
by: Do, Loi Hung, et al.
Published: (2012)