The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, February 2011.
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
| Published: |
Massachusetts Institute of Technology
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1721.1/68850 |
| _version_ | 1826205791553585152 |
|---|---|
| author | Nagaraj, Aditi |
| author2 | Jung-Hoon Chun. |
| author_facet | Jung-Hoon Chun. Nagaraj, Aditi |
| author_sort | Nagaraj, Aditi |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, February 2011. |
| first_indexed | 2024-09-23T13:19:11Z |
| format | Thesis |
| id | mit-1721.1/68850 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:19:11Z |
| publishDate | 2012 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/688502019-04-12T07:26:01Z The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets Nagaraj, Aditi Jung-Hoon Chun. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, February 2011. "February 2011." Vita. Cataloged from PDF version of thesis. Includes bibliographical references (p. 33). The design of an extruder-based continuous tablet forming process of a sample active pharmaceutical ingredient (API) and ethyl acetate requires a device to form and compress the tablets. The flow of the wet extrusion is driven by the pressure head generated by the torque of the screws; the minimum pressure head is dictated by the head loss across the exit die. Since the API powder blend and ethyl acetate solvent form a highly filled suspension paste, the liquid phase tends to flow at a different speed than the solid when the driving pressure changes. As such, the three die geometries, straight, curve, and elbow, resulted in average steady state liquid mass fraction of 0.179 ± 0.005, 0.249 + 0.01, and 0.200 ± 0.009 respectively, although the increases in mass fraction do not correspond to increases in pressure drop across the die. This experiment tests a particular tablet forming process, which involves using the pressure of the extruder to squeeze out the liquid content of the tablets during forming. The occurrence of liquid phase migration after this tabletting process is confirmed in each die tested. The extent of variation in liquid content shows a 30% increase for the straight die, a 50-200% increase for the curve die, and 50-150% increase for the elbow die. These results suggest that a tablet forming device should not use the pressure of the extruder, due to the complications of paste flow. by Aditi Nagaraj. S.B. 2012-01-30T16:54:57Z 2012-01-30T16:54:57Z 2010 2011 Thesis http://hdl.handle.net/1721.1/68850 772622200 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 33 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Nagaraj, Aditi The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| title | The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| title_full | The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| title_fullStr | The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| title_full_unstemmed | The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| title_short | The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| title_sort | effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/68850 |
| work_keys_str_mv | AT nagarajaditi theeffectofdiegeometryonextrudedpasteflowforcontinuousproductionofpharmaceuticaltablets AT nagarajaditi effectofdiegeometryonextrudedpasteflowforcontinuousproductionofpharmaceuticaltablets |