Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant
Interest has increased recently in correlations across brain regions in the resting-state fMRI blood oxygen level-dependent (BOLD) response, but little is known about the functional significance of these correlations. Here we directly test the behavioral relevance of the resting-state correlation be...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2012
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| Online Access: | http://hdl.handle.net/1721.1/69000 |
| _version_ | 1826214739230851072 |
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| author | Dilks, Daniel D. Zhu, Qi Zhang, Jiedong Luo, Yu L. L. Liu, Jia |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Dilks, Daniel D. Zhu, Qi Zhang, Jiedong Luo, Yu L. L. Liu, Jia |
| author_sort | Dilks, Daniel D. |
| collection | MIT |
| description | Interest has increased recently in correlations across brain regions in the resting-state fMRI blood oxygen level-dependent (BOLD) response, but little is known about the functional significance of these correlations. Here we directly test the behavioral relevance of the resting-state correlation between two face-selective regions in human brain, the occipital face area (OFA) and the fusiform face area (FFA). We found that the magnitude of the resting-state correlation, henceforth called functional connectivity (FC), between OFA and FFA correlates with an individual's performance on a number of face-processing tasks, not non-face tasks. Further, we found that the behavioral significance of the OFA/FFA FC is independent of the functional activation and the anatomical size of either the OFA or FFA, suggesting that face processing depends not only on the functionality of individual face-selective regions, but also on the synchronized spontaneous neural activity between them. Together, these findings provide strong evidence that the functional correlations in the BOLD response observed at rest reveal functionally significant properties of cortical processing. |
| first_indexed | 2024-09-23T16:10:22Z |
| format | Article |
| id | mit-1721.1/69000 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:10:22Z |
| publishDate | 2012 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/690002022-10-02T06:50:04Z Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant Dilks, Daniel D. Zhu, Qi Zhang, Jiedong Luo, Yu L. L. Liu, Jia McGovern Institute for Brain Research at MIT Dilks, Daniel D. Dilks, Daniel D. Interest has increased recently in correlations across brain regions in the resting-state fMRI blood oxygen level-dependent (BOLD) response, but little is known about the functional significance of these correlations. Here we directly test the behavioral relevance of the resting-state correlation between two face-selective regions in human brain, the occipital face area (OFA) and the fusiform face area (FFA). We found that the magnitude of the resting-state correlation, henceforth called functional connectivity (FC), between OFA and FFA correlates with an individual's performance on a number of face-processing tasks, not non-face tasks. Further, we found that the behavioral significance of the OFA/FFA FC is independent of the functional activation and the anatomical size of either the OFA or FFA, suggesting that face processing depends not only on the functionality of individual face-selective regions, but also on the synchronized spontaneous neural activity between them. Together, these findings provide strong evidence that the functional correlations in the BOLD response observed at rest reveal functionally significant properties of cortical processing. Chinese Academy of Sciences (100 Talents Program) National Basic Research Program of China (2010CB833903) National Basic Research Program of China (2011CB505402) Fundamental Research Funds for the Central Universities of China 2012-02-01T20:33:49Z 2012-02-01T20:33:49Z 2011-07 2011-05 Article http://purl.org/eprint/type/JournalArticle 0270-6474 1529-2401 http://hdl.handle.net/1721.1/69000 Zhu, Q. et al. “Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant.” Journal of Neuroscience 31.28 (2011): 10323-10330. Web. 1 Feb. 2012. en_US http://dx.doi.org/10.1523/jneurosci.0873-11.2011 Journal of Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society for Neuroscience SFN |
| spellingShingle | Dilks, Daniel D. Zhu, Qi Zhang, Jiedong Luo, Yu L. L. Liu, Jia Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant |
| title | Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant |
| title_full | Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant |
| title_fullStr | Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant |
| title_full_unstemmed | Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant |
| title_short | Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant |
| title_sort | resting state neural activity across face selective cortical regions is behaviorally relevant |
| url | http://hdl.handle.net/1721.1/69000 |
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