Application of microtechnologies for the vascularization of engineered tissues
Recent advances in medicine and healthcare allow people to live longer, increasing the need for the number of organ transplants. However, the number of organ donors has not been able to meet the demand, resulting in an organ shortage. The field of tissue engineering has emerged to produce organs to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2012
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| Online Access: | http://hdl.handle.net/1721.1/69018 |
| _version_ | 1826215213874020352 |
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| author | Gauvin, Robert Guillemette, Maxime D. Khademhosseini, Ali Dokmeci, Mehmet R. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Gauvin, Robert Guillemette, Maxime D. Khademhosseini, Ali Dokmeci, Mehmet R. |
| author_sort | Gauvin, Robert |
| collection | MIT |
| description | Recent advances in medicine and healthcare allow people to live longer, increasing the need for the number of organ transplants. However, the number of organ donors has not been able to meet the demand, resulting in an organ shortage. The field of tissue engineering has emerged to produce organs to overcome this limitation. While tissue engineering of connective tissues such as skin and blood vessels have currently reached clinical studies, more complex organs are still far away from commercial availability due to pending challenges with in vitro engineering of 3D tissues. One of the major limitations of engineering large tissue structures is cell death resulting from the inability of nutrients to diffuse across large distances inside a scaffold. This task, carried out by the vasculature inside the body, has largely been described as one of the foremost important challenges in engineering 3D tissues since it remains one of the key steps for both in vitro production of tissue engineered construct and the in vivo integration of a transplanted tissue. This short review highlights the important challenges for vascularization and control of the microcirculatory system within engineered tissues, with particular emphasis on the use of microfabrication approaches. |
| first_indexed | 2024-09-23T16:19:10Z |
| format | Article |
| id | mit-1721.1/69018 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:19:10Z |
| publishDate | 2012 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/690182022-10-02T07:41:12Z Application of microtechnologies for the vascularization of engineered tissues Gauvin, Robert Guillemette, Maxime D. Khademhosseini, Ali Dokmeci, Mehmet R. Harvard University--MIT Division of Health Sciences and Technology Koch Institute for Integrative Cancer Research at MIT Gauvin, Robert Guillemette, Maxime D. Dokmeci, Mehmet Khademhosseini, Ali Recent advances in medicine and healthcare allow people to live longer, increasing the need for the number of organ transplants. However, the number of organ donors has not been able to meet the demand, resulting in an organ shortage. The field of tissue engineering has emerged to produce organs to overcome this limitation. While tissue engineering of connective tissues such as skin and blood vessels have currently reached clinical studies, more complex organs are still far away from commercial availability due to pending challenges with in vitro engineering of 3D tissues. One of the major limitations of engineering large tissue structures is cell death resulting from the inability of nutrients to diffuse across large distances inside a scaffold. This task, carried out by the vasculature inside the body, has largely been described as one of the foremost important challenges in engineering 3D tissues since it remains one of the key steps for both in vitro production of tissue engineered construct and the in vivo integration of a transplanted tissue. This short review highlights the important challenges for vascularization and control of the microcirculatory system within engineered tissues, with particular emphasis on the use of microfabrication approaches. National Institutes of Health (U.S.) (EB008392) National Institutes of Health (U.S.) (HL092836) National Institutes of Health (U.S.) (HL099073) National Institutes of Health (U.S.) (EB009196) National Institutes of Health (U.S.) (DE019024) National Science Foundation (U.S.) (DMR0847287) United States. Army Research Office (Institute for Soldier Nanotechnologies) United States. Office of Naval Research United States. Army. Corps of Engineers 2012-02-02T20:39:40Z 2012-02-02T20:39:40Z 2011-10 2011-12-12T20:06:31Z Article http://purl.org/eprint/type/JournalArticle 2045-824X http://hdl.handle.net/1721.1/69018 Gauvin, Robert et al. “Application of Microtechnologies for the Vascularization of Engineered Tissues.” Vascular Cell 3.1 (2011): 24. en http://dx.doi.org/10.1186/2045-824X-3-24 Vascular Cell Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Gauvin et al.; licensee BioMed Central Ltd. application/pdf BioMed Central Ltd BioMed Central Ltd |
| spellingShingle | Gauvin, Robert Guillemette, Maxime D. Khademhosseini, Ali Dokmeci, Mehmet R. Application of microtechnologies for the vascularization of engineered tissues |
| title | Application of microtechnologies for the vascularization of engineered tissues |
| title_full | Application of microtechnologies for the vascularization of engineered tissues |
| title_fullStr | Application of microtechnologies for the vascularization of engineered tissues |
| title_full_unstemmed | Application of microtechnologies for the vascularization of engineered tissues |
| title_short | Application of microtechnologies for the vascularization of engineered tissues |
| title_sort | application of microtechnologies for the vascularization of engineered tissues |
| url | http://hdl.handle.net/1721.1/69018 |
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