The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study

The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study

Background In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). To refine our understanding of the...

Full description

Bibliographic Details
Main Author:	Hafler, David A.
Other Authors:	Harvard University--MIT Division of Health Sciences and Technology
Format:	Article
Language:	en_US
Published:	Public Library of Science 2012
Online Access:	http://hdl.handle.net/1721.1/69041

Similar Items

The Role of IRF8 Polymorphisms in Systemic Sclerosis Development and Pathogenesis
by: Anna Mennella, et al.
Published: (2024-03-01)

Genetic variant classification by predicted protein structure: A case study on IRF6
by: Hemma Murali, et al.
Published: (2024-12-01)

The role of the CD[subscript 5]8 locus in multiple sclerosis
by: De Jager, Philip L., et al.
Published: (2009)

Pathogenic CD8(+) T cells in multiple sclerosis.
by: Friese, M, et al.
Published: (2009)

Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.
by: Salzer, U, et al.
Published: (2009)

Relevance of biallelic vs monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes
by: Salzer, US, et al.
Published: (2008)

The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells
by: Hui Yan, et al.
Published: (2023-11-01)

CD8+ T cell-associated genes MS4A1 and TNFRSF17 are prognostic markers and inhibit the progression of colon cancer
by: Ye Song, et al.
Published: (2022-09-01)

Fatty Acid Metabolism and T Cells in Multiple Sclerosis
by: Saige L. Pompura, et al.
Published: (2022-05-01)

Functional characterisation of a multiple sclerosis-associated genetic variant
by: Gregory, A
Published: (2012)

CD137 as an Attractive T Cell Co-Stimulatory Target in the TNFRSF for Immuno-Oncology Drug Development
by: Kenji Hashimoto
Published: (2021-05-01)

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.
by: Giraud, M, et al.
Published: (2007)

Novel frameshift variants expand the map of the genetic defects in IRF2BP2
by: José María García-Aznar, et al.
Published: (2023-10-01)

Novel IRF6 variant in orofacial cleft patients from Durban, South Africa
by: Thirona Naicker, et al.
Published: (2023-05-01)

Pathogenic CD8 T cells in Multiple Sclerosis and its experimental models
by: Eric S. Huseby, et al.
Published: (2012-03-01)

IRF8: Mechanism of Action and Health Implications
by: Hannah R. Moorman, et al.
Published: (2022-08-01)

Autoreactive CD8+ T cells in multiple sclerosis: A new target for therapy?
by: Friese, M, et al.
Published: (2005)

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?
by: Friese, M, et al.
Published: (2005)

<i>TNFRSF1B</i> Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma
by: Bruna Fernandes Carvalho, et al.
Published: (2024-03-01)

TNFα Causes a Shift in Gene Expression of <i>TNFRSF1A</i> and <i>TNFRSF1B</i> Isoforms
by: Olga Perik-Zavodskaia, et al.
Published: (2023-05-01)

AGE-RELATED DIFFERENTIATION OF SIRT1 GENETIC VARIANTS IN MULTIPLE SCLEROSIS
by: Kriste Kaikaryte, et al.
Published: (2023-10-01)

Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury
by: Shangxun Zhou, et al.
Published: (2022-01-01)

Editorial: TNFRSF agonists: mode of action and therapeutic opportunities
by: Nataša Obermajer, et al.
Published: (2023-11-01)

On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function
by: Éva S. Vanamee, et al.
Published: (2020-03-01)

CD11c+ and IRF8+ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy
by: Benita C. Y. Tse, et al.
Published: (2023-12-01)

Nebulized Mycobacterium vaccae protects against asthma by attenuating the imbalance of IRF4/IRF8 expression in dendritic cells
by: Qi-Xiang Sun, et al.
Published: (2022-01-01)

Genetics of multiple sclerosis (vol 6, pg 1693, 1997)
by: Dyment, D, et al.
Published: (1997)

The Impact of Cytomegalovirus Infection on Natural Killer and CD8+ T Cell Phenotype in Multiple Sclerosis
by: Valentina Perri, et al.
Published: (2024-02-01)

Genetics of multiple sclerosis.
by: Dyment, D, et al.
Published: (2004)

Genetics of multiple sclerosis.
by: Ebers, G, et al.
Published: (1998)

Genetics of multiple sclerosis.
by: Dyment, D, et al.
Published: (1997)

Genetics of multiple sclerosis.
by: Sadovnick, A, et al.
Published: (1995)

IRF8 is crucial for the nicotine withdrawal-induced hyperalgesia in mice
by: Guo Lina, et al.
Published: (2020-09-01)

Alterations in bone fracture healing associated with TNFRSF signaling pathways
by: Yanzhao Dong, et al.
Published: (2022-10-01)

Treatment of multiple sclerosis with rituximab: A Spanish multicenter experience
by: Francisco Gascón-Giménez, et al.
Published: (2023-03-01)

A Null Mutation of TNFRSF11A Causes Dysosteosclerosis, Not Osteopetrosis
by: Tarık Kırkgöz, et al.
Published: (2022-06-01)

Distinct Effector Programs of Brain-Homing CD8<sup>+</sup> T Cells in Multiple Sclerosis
by: Steven C. Koetzier, et al.
Published: (2022-05-01)

Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis
by: Tobias Burkard, et al.
Published: (2022-12-01)

Erratum: Genetics of multiple sclerosis (Human Molecular Genetics (1997) 6 (1693-1698))
by: Dyment, D, et al.
Published: (1997)

RANK (TNFRSF11A) Is Epigenetically Inactivated and Induces Apoptosis in Gliomas
by: Anna von dem Knesebeck, et al.
Published: (2012-06-01)