Striatal origin of the pathologic beta oscillations in Parkinson's disease
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10. 1073/pnas.1107748108/-/DCSupplemental.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Proceedings of the National Academy of Sciences (PNAS)
2012
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| Online Access: | http://hdl.handle.net/1721.1/69054 https://orcid.org/0000-0002-0419-3351 |
| _version_ | 1811069706760617984 |
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| author | McCarthy, M. M. Moore-Kochlacs, Caroline Gu, X. Han, X. Kopell, Nancy J. Boyden, Edward |
| author2 | Massachusetts Institute of Technology. Media Laboratory |
| author_facet | Massachusetts Institute of Technology. Media Laboratory McCarthy, M. M. Moore-Kochlacs, Caroline Gu, X. Han, X. Kopell, Nancy J. Boyden, Edward |
| author_sort | McCarthy, M. M. |
| collection | MIT |
| description | This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.
1073/pnas.1107748108/-/DCSupplemental. |
| first_indexed | 2024-09-23T08:14:38Z |
| format | Article |
| id | mit-1721.1/69054 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:14:38Z |
| publishDate | 2012 |
| publisher | Proceedings of the National Academy of Sciences (PNAS) |
| record_format | dspace |
| spelling | mit-1721.1/690542022-09-23T11:51:40Z Striatal origin of the pathologic beta oscillations in Parkinson's disease McCarthy, M. M. Moore-Kochlacs, Caroline Gu, X. Han, X. Kopell, Nancy J. Boyden, Edward Massachusetts Institute of Technology. Media Laboratory Program in Media Arts and Sciences (Massachusetts Institute of Technology) Boyden, Edward Stuart Boyden, Edward Stuart This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10. 1073/pnas.1107748108/-/DCSupplemental. Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations remain elusive. Here, using mathematical models, we find that robust beta oscillations can emerge from inhibitory interactions between striatal medium spiny neurons. The interaction of the synaptic GABAa currents and the intrinsic membrane M-current promotes population oscillations in the beta frequency range. Increased levels of cholinergic drive, a condition relevant to the parkinsonian striatum, lead to enhanced beta oscillations in the striatal model. We show experimentally that direct infusion of the cholinergic agonist carbachol into the striatum, but not into the neighboring cortex, of the awake, normal rodent induces prominent beta frequency oscillations in the local field potential. These results provide evidence for amplification of normal striatal network dynamics as a mechanism responsible for the enhanced beta frequency oscillations in Parkinson's disease. National Science Foundation (U.S.). (Grant DMS-0717670) National Science Foundation (U.S.). (Director’s New Innovator Award DP2 OD002002-01) Helen Hay Whitney Foundation Fellowship United States. National Institutes of Health (Grant K99MH085944) National Institute of Neurological Disorders and Stroke (U.S.) (Grant 1 R01 NS062955-01) 2012-02-08T20:59:06Z 2012-02-08T20:59:06Z 2011-06 2011-05 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/69054 McCarthy, M. M. et al. “Striatal Origin of the Pathologic Beta Oscillations in Parkinson’s Disease.” Proceedings of the National Academy of Sciences 108.28 (2011): 11620-11625. Web. 8 Feb. 2012. © 2011 American Physical Society https://orcid.org/0000-0002-0419-3351 en_US http://dx.doi.org/10.1073/pnas.1107748108 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences (PNAS) PNAS |
| spellingShingle | McCarthy, M. M. Moore-Kochlacs, Caroline Gu, X. Han, X. Kopell, Nancy J. Boyden, Edward Striatal origin of the pathologic beta oscillations in Parkinson's disease |
| title | Striatal origin of the pathologic beta oscillations in Parkinson's disease |
| title_full | Striatal origin of the pathologic beta oscillations in Parkinson's disease |
| title_fullStr | Striatal origin of the pathologic beta oscillations in Parkinson's disease |
| title_full_unstemmed | Striatal origin of the pathologic beta oscillations in Parkinson's disease |
| title_short | Striatal origin of the pathologic beta oscillations in Parkinson's disease |
| title_sort | striatal origin of the pathologic beta oscillations in parkinson s disease |
| url | http://hdl.handle.net/1721.1/69054 https://orcid.org/0000-0002-0419-3351 |
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