Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators
Using suspended nanochannel resonators (SNRs) we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society
2012
|
| Online Access: | http://hdl.handle.net/1721.1/69077 https://orcid.org/0000-0001-5223-9433 |
| _version_ | 1826189145532268544 |
|---|---|
| author | Lee, Jungchul Shen, Wenjiang Payer, Kristofor Robert Burg, Thomas P. Manalis, Scott R. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Lee, Jungchul Shen, Wenjiang Payer, Kristofor Robert Burg, Thomas P. Manalis, Scott R. |
| author_sort | Lee, Jungchul |
| collection | MIT |
| description | Using suspended nanochannel resonators (SNRs) we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today. The SNR consists of a cantilever that is 50 μm long, 10 μm wide, and 1.3 μm thick, with an embedded nanochannel that is 2 μm wide and 700 nm tall. The SNR has a resonance frequency near 630 kHz and exhibits a quality factor of approximately 8,000 when dry and when filled with water. In addition, we introduce a new method that uses centrifugal force caused by vibration of the cantilever to trap particles at the free end. This approach eliminates the intrinsic position dependent error of the SNR and also improves the mass resolution by increasing the averaging time for each particle. |
| first_indexed | 2024-09-23T08:10:13Z |
| format | Article |
| id | mit-1721.1/69077 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:10:13Z |
| publishDate | 2012 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | mit-1721.1/690772022-09-23T11:21:48Z Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators Lee, Jungchul Shen, Wenjiang Payer, Kristofor Robert Burg, Thomas P. Manalis, Scott R. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Microsystems Technology Laboratories Manalis, Scott R. Manalis, Scott R. Lee, Jungchul Payer, Kristofor Robert Using suspended nanochannel resonators (SNRs) we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today. The SNR consists of a cantilever that is 50 μm long, 10 μm wide, and 1.3 μm thick, with an embedded nanochannel that is 2 μm wide and 700 nm tall. The SNR has a resonance frequency near 630 kHz and exhibits a quality factor of approximately 8,000 when dry and when filled with water. In addition, we introduce a new method that uses centrifugal force caused by vibration of the cantilever to trap particles at the free end. This approach eliminates the intrinsic position dependent error of the SNR and also improves the mass resolution by increasing the averaging time for each particle. Center for Integration of Medicine and Innovative Technology (CIMIT Contract 09-440) United States. Army Research Office (Institute for Collaborative Biotechnologies Grant (DAAD1903D0004)) Max Planck Institute for Biophysical Chemistry 2012-02-10T16:39:39Z 2012-02-10T16:39:39Z 2011-07 2010-03 Article http://purl.org/eprint/type/JournalArticle 1530-6984 1530-6992 http://hdl.handle.net/1721.1/69077 Lee, Jungchul et al. “Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators.” Nano Letters 10.7 (2010): 2537-2542. https://orcid.org/0000-0001-5223-9433 en_US http://dx.doi.org/10.1021/nl101107u Nano Letters Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf American Chemical Society Prof. Manalis via Howard Silver |
| spellingShingle | Lee, Jungchul Shen, Wenjiang Payer, Kristofor Robert Burg, Thomas P. Manalis, Scott R. Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators |
| title | Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators |
| title_full | Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators |
| title_fullStr | Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators |
| title_full_unstemmed | Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators |
| title_short | Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators |
| title_sort | towards attogram mass measurements in solution with suspended nanochannel resonators |
| url | http://hdl.handle.net/1721.1/69077 https://orcid.org/0000-0001-5223-9433 |
| work_keys_str_mv | AT leejungchul towardsattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT shenwenjiang towardsattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT payerkristoforrobert towardsattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT burgthomasp towardsattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT manalisscottr towardsattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT leejungchul towardattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT shenwenjiang towardattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT payerkristoforrobert towardattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT burgthomasp towardattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators AT manalisscottr towardattogrammassmeasurementsinsolutionwithsuspendednanochannelresonators |