Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation
We describe the amplitude and resolution trends of the signals acquired by turbidity suppression through optical phase conjugation (TSOPC) with samples that span the ballistic and diffusive scattering regimes. In these experiments, the light field scattered through a turbid material is written into...
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| Format: | Article |
| Language: | en_US |
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SPIE - International Society for Optical Engineering
2012
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| Online Access: | http://hdl.handle.net/1721.1/69124 |
| _version_ | 1826205611763695616 |
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| author | McDowell, Emily J. Cui, Meng Senekerimyan, Vahan Vellekoop, Ivo M. Yang, Changhuei Yaqoob, Zahid |
| author2 | Massachusetts Institute of Technology. Spectroscopy Laboratory |
| author_facet | Massachusetts Institute of Technology. Spectroscopy Laboratory McDowell, Emily J. Cui, Meng Senekerimyan, Vahan Vellekoop, Ivo M. Yang, Changhuei Yaqoob, Zahid |
| author_sort | McDowell, Emily J. |
| collection | MIT |
| description | We describe the amplitude and resolution trends of the signals acquired by turbidity suppression through optical phase conjugation (TSOPC) with samples that span the ballistic and diffusive scattering regimes. In these experiments, the light field scattered through a turbid material is written into a hologram, and a time-reversed copy of the light field is played back through the sample. In this manner, the wavefront originally incident on the sample is reconstructed. We examine a range of scattering samples including chicken breast tissue sections of increasing thickness and polyacrylamide tissue-mimicking phantoms with increasing scattering coefficients. Our results indicate that only a small portion of the scattered wavefront (<0.02%) must be collected to reconstruct a TSOPC signal. Provided the sample is highly scattering, all essential angular information is contained within such small portions of the scattered wavefront due to randomization by scattering. A model is fitted to our results, describing the dependence of the TSOPC signal on other measurable values within the system and shedding light on the efficiency of the phase conjugation process. Our results describe the highest level of scattering that has been phase conjugated in biological tissues to date. |
| first_indexed | 2024-09-23T13:15:50Z |
| format | Article |
| id | mit-1721.1/69124 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:15:50Z |
| publishDate | 2012 |
| publisher | SPIE - International Society for Optical Engineering |
| record_format | dspace |
| spelling | mit-1721.1/691242022-09-28T13:00:08Z Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation McDowell, Emily J. Cui, Meng Senekerimyan, Vahan Vellekoop, Ivo M. Yang, Changhuei Yaqoob, Zahid Massachusetts Institute of Technology. Spectroscopy Laboratory Yaqoob, Zahid Yaqoob, Zahid We describe the amplitude and resolution trends of the signals acquired by turbidity suppression through optical phase conjugation (TSOPC) with samples that span the ballistic and diffusive scattering regimes. In these experiments, the light field scattered through a turbid material is written into a hologram, and a time-reversed copy of the light field is played back through the sample. In this manner, the wavefront originally incident on the sample is reconstructed. We examine a range of scattering samples including chicken breast tissue sections of increasing thickness and polyacrylamide tissue-mimicking phantoms with increasing scattering coefficients. Our results indicate that only a small portion of the scattered wavefront (<0.02%) must be collected to reconstruct a TSOPC signal. Provided the sample is highly scattering, all essential angular information is contained within such small portions of the scattered wavefront due to randomization by scattering. A model is fitted to our results, describing the dependence of the TSOPC signal on other measurable values within the system and shedding light on the efficiency of the phase conjugation process. Our results describe the highest level of scattering that has been phase conjugated in biological tissues to date. National Science Foundation (U.S.) (Grant No. BES-0547657) National Institutes of Health (U.S.) (Grant No. R21 EB008866-01) National Science Foundation (U.S.). Graduate Research Fellowship Program 2012-02-15T20:05:11Z 2012-02-15T20:05:11Z 2010-04 2010-02 Article http://purl.org/eprint/type/JournalArticle 1083-3668 1560-2281 http://hdl.handle.net/1721.1/69124 McDowell, Emily J. et al. “Turbidity Suppression from the Ballistic to the Diffusive Regime in Biological Tissues Using Optical Phase Conjugation.” Journal of Biomedical Optics 15.2 (2010): 025004. Web. 15 Feb. 2012. © 2010 SPIE - International Society for Optical Engineering en_US http://dx.doi.org/10.1117/1.3381188 Journal of Biomedical Optics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE - International Society for Optical Engineering SPIE |
| spellingShingle | McDowell, Emily J. Cui, Meng Senekerimyan, Vahan Vellekoop, Ivo M. Yang, Changhuei Yaqoob, Zahid Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| title | Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| title_full | Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| title_fullStr | Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| title_full_unstemmed | Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| title_short | Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| title_sort | turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugation |
| url | http://hdl.handle.net/1721.1/69124 |
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