Capacity-Speed Relationships in Prefrontal Cortex
Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this int...
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| Materialtyp: | Artikel |
| Språk: | en_US |
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Public Library of Science
2012
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| Länkar: | http://hdl.handle.net/1721.1/69166 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1826189476547788800 |
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| author | Prabhakaran, Vivek Rypma, Bart Narayanan, Nandakumar S. Meier, Timothy B. Austin, Benjamin P. Nair, Veena A. Naing, Lin Thomas, Lisa E. Gabrieli, John D. E. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Prabhakaran, Vivek Rypma, Bart Narayanan, Nandakumar S. Meier, Timothy B. Austin, Benjamin P. Nair, Veena A. Naing, Lin Thomas, Lisa E. Gabrieli, John D. E. |
| author_sort | Prabhakaran, Vivek |
| collection | MIT |
| description | Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in capacity and speed. Experiment 1, using a block-design WM verbal task, identified increased WM capacity with increased activity in right prefrontal regions, and Experiment 2, using a single-trial WM verbal task, identified increased WM processing speed with increased activity in similar regions. Our results suggest that right prefrontal areas may be a common region interlinking these two cognitive measures. Moreover, an overlap analysis with regions associated with binding or chunking suggest that this strategic memory consolidation process may be the mechanism interlinking WM capacity and WM speed. |
| first_indexed | 2024-09-23T08:15:20Z |
| format | Article |
| id | mit-1721.1/69166 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:15:20Z |
| publishDate | 2012 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/691662022-09-30T08:37:41Z Capacity-Speed Relationships in Prefrontal Cortex Prabhakaran, Vivek Rypma, Bart Narayanan, Nandakumar S. Meier, Timothy B. Austin, Benjamin P. Nair, Veena A. Naing, Lin Thomas, Lisa E. Gabrieli, John D. E. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gabrieli, John D. E. Gabrieli, John D. E. Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in capacity and speed. Experiment 1, using a block-design WM verbal task, identified increased WM capacity with increased activity in right prefrontal regions, and Experiment 2, using a single-trial WM verbal task, identified increased WM processing speed with increased activity in similar regions. Our results suggest that right prefrontal areas may be a common region interlinking these two cognitive measures. Moreover, an overlap analysis with regions associated with binding or chunking suggest that this strategic memory consolidation process may be the mechanism interlinking WM capacity and WM speed. National Center for Research Resources (U.S.) (grant UL1RR025011) National Institutes of Health (U.S.) (grant NIH RO1 DC05375) Wallace H. Coulter Foundation National Institute of Mental Health (U.S.) (Challenge Grant RC1MH090912-01) 2012-02-23T17:26:07Z 2012-02-23T17:26:07Z 2011-11 2011-04 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/69166 Prabhakaran, Vivek et al. “Capacity-Speed Relationships in Prefrontal Cortex.” Ed. André Aleman. PLoS ONE 6.11 (2011): e27504. Web. 23 Feb. 2012. https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1371/journal.pone.0027504 PLoS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/2.5/ application/pdf Public Library of Science PLoS |
| spellingShingle | Prabhakaran, Vivek Rypma, Bart Narayanan, Nandakumar S. Meier, Timothy B. Austin, Benjamin P. Nair, Veena A. Naing, Lin Thomas, Lisa E. Gabrieli, John D. E. Capacity-Speed Relationships in Prefrontal Cortex |
| title | Capacity-Speed Relationships in Prefrontal Cortex |
| title_full | Capacity-Speed Relationships in Prefrontal Cortex |
| title_fullStr | Capacity-Speed Relationships in Prefrontal Cortex |
| title_full_unstemmed | Capacity-Speed Relationships in Prefrontal Cortex |
| title_short | Capacity-Speed Relationships in Prefrontal Cortex |
| title_sort | capacity speed relationships in prefrontal cortex |
| url | http://hdl.handle.net/1721.1/69166 https://orcid.org/0000-0003-1158-5692 |
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