Trial Outcome and Associative Learning Signals in the Monkey Hippocampus
In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded associations and modify incorrect/unrewarded ones. To study how hippocampal neurons convey information about reward and trial outcome during n...
| প্রধান লেখক: | , , , , , , |
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| অন্যান্য লেখক: | |
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | en_US |
| প্রকাশিত: |
Elsevier B.V.
2012
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| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/1721.1/69540 https://orcid.org/0000-0003-2668-7819 |
| _version_ | 1826199133982031872 |
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| author | Wirth, Sylvia Avsar, Emin Chiu, Cindy C. Sharma, Varun Smith, Anne C. Brown, Emery N. Suzuki, Wendy A. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Wirth, Sylvia Avsar, Emin Chiu, Cindy C. Sharma, Varun Smith, Anne C. Brown, Emery N. Suzuki, Wendy A. |
| author_sort | Wirth, Sylvia |
| collection | MIT |
| description | In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded associations and modify incorrect/unrewarded ones. To study how hippocampal neurons convey information about reward and trial outcome during new associative learning, we recorded hippocampal neurons as monkeys learned novel object-place associations. A large population of hippocampal neurons (50%) signaled trial outcome by differentiating between correct and error trials during the period after the behavioral response. About half these cells increased their activity following correct trials (correct up cells) while the remaining half fired more following error trials (error up cells). Moreover, correct up cells, but not error up cells, conveyed information about learning by increasing their stimulus-selective response properties with behavioral learning. These findings suggest that information about successful trial outcome conveyed by correct up cells may influence new associative learning through changes in the cell's stimulus-selective response properties. |
| first_indexed | 2024-09-23T11:14:56Z |
| format | Article |
| id | mit-1721.1/69540 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:14:56Z |
| publishDate | 2012 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/695402022-09-27T18:08:38Z Trial Outcome and Associative Learning Signals in the Monkey Hippocampus Wirth, Sylvia Avsar, Emin Chiu, Cindy C. Sharma, Varun Smith, Anne C. Brown, Emery N. Suzuki, Wendy A. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Brown, Emery N. Brown, Emery N. In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded associations and modify incorrect/unrewarded ones. To study how hippocampal neurons convey information about reward and trial outcome during new associative learning, we recorded hippocampal neurons as monkeys learned novel object-place associations. A large population of hippocampal neurons (50%) signaled trial outcome by differentiating between correct and error trials during the period after the behavioral response. About half these cells increased their activity following correct trials (correct up cells) while the remaining half fired more following error trials (error up cells). Moreover, correct up cells, but not error up cells, conveyed information about learning by increasing their stimulus-selective response properties with behavioral learning. These findings suggest that information about successful trial outcome conveyed by correct up cells may influence new associative learning through changes in the cell's stimulus-selective response properties. National Institutes of Health (U.S.) (NIH grant MH48847) National Institutes of Health (U.S.) (NIH Award DA015644) National Institutes of Health (U.S.) (NIH Award MH59733) National Institutes of Health (U.S.) (NIH grant MH071847) National Institutes of Health (U.S.) (NIH grant DP1 OD003646) Fondation pour la recherche médicale 2012-03-01T17:17:30Z 2012-03-01T17:17:30Z 2009-03 Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/69540 Wirth, Sylvia et al. “Trial Outcome and Associative Learning Signals in the Monkey Hippocampus.” Neuron 61.6 (2009): 930–940. https://orcid.org/0000-0003-2668-7819 en_US http://dx.doi.org/10.1016/j.neuron.2009.01.012 Neuron Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier B.V. PubMed Central |
| spellingShingle | Wirth, Sylvia Avsar, Emin Chiu, Cindy C. Sharma, Varun Smith, Anne C. Brown, Emery N. Suzuki, Wendy A. Trial Outcome and Associative Learning Signals in the Monkey Hippocampus |
| title | Trial Outcome and Associative Learning Signals in the Monkey Hippocampus |
| title_full | Trial Outcome and Associative Learning Signals in the Monkey Hippocampus |
| title_fullStr | Trial Outcome and Associative Learning Signals in the Monkey Hippocampus |
| title_full_unstemmed | Trial Outcome and Associative Learning Signals in the Monkey Hippocampus |
| title_short | Trial Outcome and Associative Learning Signals in the Monkey Hippocampus |
| title_sort | trial outcome and associative learning signals in the monkey hippocampus |
| url | http://hdl.handle.net/1721.1/69540 https://orcid.org/0000-0003-2668-7819 |
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