Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2012
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| Online Access: | http://hdl.handle.net/1721.1/69541 |
| _version_ | 1826208790618308608 |
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| author | Khibnik, Lena A. Cho, Kathleen K. Bear, Mark |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Khibnik, Lena A. Cho, Kathleen K. Bear, Mark |
| author_sort | Khibnik, Lena A. |
| collection | MIT |
| description | Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feedforward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission. |
| first_indexed | 2024-09-23T14:12:41Z |
| format | Article |
| id | mit-1721.1/69541 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:12:41Z |
| publishDate | 2012 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/695412022-09-28T19:12:23Z Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex Khibnik, Lena A. Cho, Kathleen K. Bear, Mark Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Bear, Mark Bear, Mark Cho, Kathleen K. Khibnik, Lena A. Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feedforward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission. National Institutes of Health (U.S.) 2012-03-01T17:28:10Z 2012-03-01T17:28:10Z 2010-05 2010-04 Article http://purl.org/eprint/type/JournalArticle http://hdl.handle.net/1721.1/69541 Khibnik, Lena A., Kathleen K.A. Cho, and Mark F. Bear. “Relative Contribution of Feedforward Excitatory Connections to Expression of Ocular Dominance Plasticity in Layer 4 of Visual Cortex.” Neuron 66.4 (2010): 493–500. en_US http://dx.doi.org/10.1016/j.neuron.2010.04.012 Neuron Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier B.V. PubMed Central |
| spellingShingle | Khibnik, Lena A. Cho, Kathleen K. Bear, Mark Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| title | Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| title_full | Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| title_fullStr | Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| title_full_unstemmed | Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| title_short | Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| title_sort | relative contribution of feed forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex |
| url | http://hdl.handle.net/1721.1/69541 |
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