Synthesis of Red-Shifted 8-Hydroxyquinoline Derivatives Using Click Chemistry and Their Incorporation into Phosphorylation Chemosensors

Protein phosphorylation is a ubiquitous post-translational modification, and protein kinases, the enzymes that catalyze the phosphoryl transfer, are involved in nearly every aspect of normal, as well as aberrant, cell function. Here we describe the synthesis of novel, red-shifted 8-hydroxyquinoline-...

ver descrição completa

Detalhes bibliográficos
Principais autores: Gonzalez-Vera, Juan A., Lukovic, Elvedin, Imperiali, Barbara
Outros Autores: Massachusetts Institute of Technology. Department of Biology
Formato: Artigo
Idioma:en_US
Publicado em: American Chemical Society 2012
Acesso em linha:http://hdl.handle.net/1721.1/69597
https://orcid.org/0000-0002-5749-7869