Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit
The mammalian neocortex is functionally subdivided into architectonically distinct regions that process various types of information based on their source of afferent input. Yet, the modularity of neocortical organization in terms of cell type and intrinsic circuitry allows afferent drive to continu...
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2012
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| Online Access: | http://hdl.handle.net/1721.1/69623 https://orcid.org/0000-0002-1710-0767 |
| _version_ | 1826196776262041600 |
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| author | Chen, Jerry L. Flanders, Genevieve H. Lee, Wei-Chung Allen Lin, Walter C. Nedivi, Elly |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Chen, Jerry L. Flanders, Genevieve H. Lee, Wei-Chung Allen Lin, Walter C. Nedivi, Elly |
| author_sort | Chen, Jerry L. |
| collection | MIT |
| description | The mammalian neocortex is functionally subdivided into architectonically distinct regions that process various types of information based on their source of afferent input. Yet, the modularity of neocortical organization in terms of cell type and intrinsic circuitry allows afferent drive to continuously reassign cortical map space. New aspects of cortical map plasticity include dynamic turnover of dendritic spines on pyramidal neurons and remodeling of interneuron dendritic arbors. While spine remodeling occurs in multiple cortical regions, it is not yet known whether interneuron dendrite remodeling is common across primary sensory and higher-level cortices. It is also unknown whether, like pyramidal dendrites, inhibitory dendrites respect functional domain boundaries. Given the importance of the inhibitory circuitry to adult cortical plasticity and the reorganization of cortical maps, we sought to address these questions by using two-photon microscopy to monitor interneuron dendritic arbors of thy1-GFP-S transgenic mice expressing GFP in neurons sparsely distributed across the superficial layers of the neocortex. We find that interneuron dendritic branch tip remodeling is a general feature of the adult cortical microcircuit, and that remodeling rates are similar across primary sensory regions of different modalities, but may differ in magnitude between primary sensory versus higher cortical areas. We also show that branch tip remodeling occurs in bursts and respects functional domain boundaries. |
| first_indexed | 2024-09-23T10:37:30Z |
| format | Article |
| id | mit-1721.1/69623 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:37:30Z |
| publishDate | 2012 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/696232022-09-27T10:07:23Z Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit Chen, Jerry L. Flanders, Genevieve H. Lee, Wei-Chung Allen Lin, Walter C. Nedivi, Elly Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Nedivi, Elly Chen, Jerry L. Flanders, Genevieve H. Lee, Wei-Chung Allen Lin, Walter C. Nedivi, Elly The mammalian neocortex is functionally subdivided into architectonically distinct regions that process various types of information based on their source of afferent input. Yet, the modularity of neocortical organization in terms of cell type and intrinsic circuitry allows afferent drive to continuously reassign cortical map space. New aspects of cortical map plasticity include dynamic turnover of dendritic spines on pyramidal neurons and remodeling of interneuron dendritic arbors. While spine remodeling occurs in multiple cortical regions, it is not yet known whether interneuron dendrite remodeling is common across primary sensory and higher-level cortices. It is also unknown whether, like pyramidal dendrites, inhibitory dendrites respect functional domain boundaries. Given the importance of the inhibitory circuitry to adult cortical plasticity and the reorganization of cortical maps, we sought to address these questions by using two-photon microscopy to monitor interneuron dendritic arbors of thy1-GFP-S transgenic mice expressing GFP in neurons sparsely distributed across the superficial layers of the neocortex. We find that interneuron dendritic branch tip remodeling is a general feature of the adult cortical microcircuit, and that remodeling rates are similar across primary sensory regions of different modalities, but may differ in magnitude between primary sensory versus higher cortical areas. We also show that branch tip remodeling occurs in bursts and respects functional domain boundaries. Nuclear Energy Institute (grant R01 EY017656) 2012-03-09T17:03:26Z 2012-03-09T17:03:26Z 2011-08 2011-06 Article http://purl.org/eprint/type/JournalArticle 0270-6474 1529-2401 http://hdl.handle.net/1721.1/69623 Chen, J. L. et al. “Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit.” Journal of Neuroscience 31.35 (2011): 12437-12443. 21880904 https://orcid.org/0000-0002-1710-0767 en_US http://dx.doi.org/10.1523/jneurosci.0420-11.2011 Journal of Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society for Neuroscience PNAS |
| spellingShingle | Chen, Jerry L. Flanders, Genevieve H. Lee, Wei-Chung Allen Lin, Walter C. Nedivi, Elly Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit |
| title | Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit |
| title_full | Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit |
| title_fullStr | Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit |
| title_full_unstemmed | Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit |
| title_short | Inhibitory Dendrite Dynamics as a General Feature of the Adult Cortical Microcircuit |
| title_sort | inhibitory dendrite dynamics as a general feature of the adult cortical microcircuit |
| url | http://hdl.handle.net/1721.1/69623 https://orcid.org/0000-0002-1710-0767 |
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