Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast?
In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, w...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/69914 https://orcid.org/0000-0003-1307-882X |
| _version_ | 1826206391103127552 |
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| author | Khurana, Vikram Lindquist, Susan |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Khurana, Vikram Lindquist, Susan |
| author_sort | Khurana, Vikram |
| collection | MIT |
| description | In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale. |
| first_indexed | 2024-09-23T13:29:07Z |
| format | Article |
| id | mit-1721.1/69914 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:29:07Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/699142022-10-01T15:31:12Z Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? Khurana, Vikram Lindquist, Susan Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Lindquist, Susan Khurana, Vikram Lindquist, Susan In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale. Howard Hughes Medical Institute National Institutes of Health (U.S.) (grant NS038372) Whitehead Institute for Biomedical Research (Regenerative Biology Initiative) 2012-04-04T13:27:50Z 2012-04-04T13:27:50Z 2010-06 Article http://purl.org/eprint/type/JournalArticle 1471-0048 http://hdl.handle.net/1721.1/69914 Khurana, Vikram, and Susan Lindquist. “Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast?” Nature Reviews Neuroscience 11.6 (2010): 436-449. https://orcid.org/0000-0003-1307-882X en_US http://dx.doi.org/10.1038/nrn2809 Nature Reviews Neuroscience Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group Lindquist via Courtney Crummett |
| spellingShingle | Khurana, Vikram Lindquist, Susan Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? |
| title | Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? |
| title_full | Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? |
| title_fullStr | Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? |
| title_full_unstemmed | Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? |
| title_short | Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? |
| title_sort | modelling neurodegeneration in saccharomyces cerevisiae why cook with baker s yeast |
| url | http://hdl.handle.net/1721.1/69914 https://orcid.org/0000-0003-1307-882X |
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