Single-neuron dynamics in human focal epilepsy
Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons wit...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/69926 https://orcid.org/0000-0003-2668-7819 |
| _version_ | 1826197357843185664 |
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| author | Truccolo, Wilson Donoghue, Jacob Alexander Hochberg, Leigh R. Eskandar, Emad Madsen, Joseph R. Anderson, William S. Brown, Emery N. Halgren, Eric Cash, Sydney S. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Truccolo, Wilson Donoghue, Jacob Alexander Hochberg, Leigh R. Eskandar, Emad Madsen, Joseph R. Anderson, William S. Brown, Emery N. Halgren, Eric Cash, Sydney S. |
| author_sort | Truccolo, Wilson |
| collection | MIT |
| description | Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons. |
| first_indexed | 2024-09-23T10:46:46Z |
| format | Article |
| id | mit-1721.1/69926 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:46:46Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/699262022-09-27T14:55:12Z Single-neuron dynamics in human focal epilepsy Truccolo, Wilson Donoghue, Jacob Alexander Hochberg, Leigh R. Eskandar, Emad Madsen, Joseph R. Anderson, William S. Brown, Emery N. Halgren, Eric Cash, Sydney S. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Brown, Emery N. Brown, Emery N. Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons. 2012-04-04T16:39:28Z 2012-04-04T16:39:28Z 2011-03 2010-12 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/69926 Truccolo, Wilson et al. “Single-neuron Dynamics in Human Focal Epilepsy.” Nature Neuroscience 14.5 (2011): 635–641. https://orcid.org/0000-0003-2668-7819 en_US http://dx.doi.org/10.1038/nn.2782 Nature Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PubMed Central |
| spellingShingle | Truccolo, Wilson Donoghue, Jacob Alexander Hochberg, Leigh R. Eskandar, Emad Madsen, Joseph R. Anderson, William S. Brown, Emery N. Halgren, Eric Cash, Sydney S. Single-neuron dynamics in human focal epilepsy |
| title | Single-neuron dynamics in human focal epilepsy |
| title_full | Single-neuron dynamics in human focal epilepsy |
| title_fullStr | Single-neuron dynamics in human focal epilepsy |
| title_full_unstemmed | Single-neuron dynamics in human focal epilepsy |
| title_short | Single-neuron dynamics in human focal epilepsy |
| title_sort | single neuron dynamics in human focal epilepsy |
| url | http://hdl.handle.net/1721.1/69926 https://orcid.org/0000-0003-2668-7819 |
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