Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions
Learning from experience requires knowing whether a past action resulted in a desired outcome. The prefrontal cortex and basal ganglia are thought to play key roles in such learning of arbitrary stimulus-response associations. Previous studies have found neural activity in these areas, similar to do...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2012
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| Online Access: | http://hdl.handle.net/1721.1/69950 |
| _version_ | 1826214778809352192 |
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| author | Histed, Mark H. Pasupathy, Anitha Miller, Earl K. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Histed, Mark H. Pasupathy, Anitha Miller, Earl K. |
| author_sort | Histed, Mark H. |
| collection | MIT |
| description | Learning from experience requires knowing whether a past action resulted in a desired outcome. The prefrontal cortex and basal ganglia are thought to play key roles in such learning of arbitrary stimulus-response associations. Previous studies have found neural activity in these areas, similar to dopaminergic neurons' signals, that transiently reflect whether a response is correct or incorrect. However, it is unclear how this transient activity, which fades in under a second, influences actions that occur much later. Here, we report that single neurons in both areas show sustained, persistent outcome-related responses. Moreover, single behavioral outcomes influence future neural activity and behavior: behavioral responses are more often correct and single neurons more accurately discriminate between the possible responses when the previous response was correct. These long-lasting signals about trial outcome provide a way to link one action to the next and may allow reward signals to be combined over time to implement successful learning. |
| first_indexed | 2024-09-23T16:11:00Z |
| format | Article |
| id | mit-1721.1/69950 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:11:00Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/699502022-10-02T06:54:10Z Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions Histed, Mark H. Pasupathy, Anitha Miller, Earl K. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Miller, Earl K. Histed, Mark H. Pasupathy, Anitha Miller, Earl K. Learning from experience requires knowing whether a past action resulted in a desired outcome. The prefrontal cortex and basal ganglia are thought to play key roles in such learning of arbitrary stimulus-response associations. Previous studies have found neural activity in these areas, similar to dopaminergic neurons' signals, that transiently reflect whether a response is correct or incorrect. However, it is unclear how this transient activity, which fades in under a second, influences actions that occur much later. Here, we report that single neurons in both areas show sustained, persistent outcome-related responses. Moreover, single behavioral outcomes influence future neural activity and behavior: behavioral responses are more often correct and single neurons more accurately discriminate between the possible responses when the previous response was correct. These long-lasting signals about trial outcome provide a way to link one action to the next and may allow reward signals to be combined over time to implement successful learning. National Institute of Neurological Disorders and Stroke (U.S.) Tourette Syndrome Association 2012-04-05T16:17:29Z 2012-04-05T16:17:29Z 2009-07 2009-06 Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/69950 Histed, Mark H., Anitha Pasupathy, and Earl K. Miller. “Learning Substrates in the Primate Prefrontal Cortex and Striatum: Sustained Activity Related to Successful Actions.” Neuron 63.2 (2009): 244–253. Web. 5 Apr. 2012. en_US http://dx.doi.org/10.1016/j.neuron.2009.06.019 Neuron Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier PubMed Central |
| spellingShingle | Histed, Mark H. Pasupathy, Anitha Miller, Earl K. Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions |
| title | Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions |
| title_full | Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions |
| title_fullStr | Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions |
| title_full_unstemmed | Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions |
| title_short | Learning substrates in the primate prefrontal cortex and striatum: = activity related to successful actions |
| title_sort | learning substrates in the primate prefrontal cortex and striatum activity related to successful actions |
| url | http://hdl.handle.net/1721.1/69950 |
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