Hippocampal function is not required for the precision of remote place memory
Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of original place memories also transforms from a precise form to a less precise form...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central Ltd
2012
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| Online Access: | http://hdl.handle.net/1721.1/69969 |
| _version_ | 1826204658997133312 |
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| author | Kitamura, Takashi Okubo-suzuki, Reiko Takashima, Noriko Murayama, Akiko Hino, Toshiaki Nishizono, Hirofumi Kida, Satoshi Inokuchi, Kaoru |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Kitamura, Takashi Okubo-suzuki, Reiko Takashima, Noriko Murayama, Akiko Hino, Toshiaki Nishizono, Hirofumi Kida, Satoshi Inokuchi, Kaoru |
| author_sort | Kitamura, Takashi |
| collection | MIT |
| description | Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of original place memories also transforms from a precise form to a less precise form with similar time course. The question arises of whether the quality of original place memories is determined by brain regions on which the memory depends. Results: To directly test this idea, we introduced a new procedure: a non-associative place recognition memory test in mice. Combined with genetic and pharmacological approaches, our analyses revealed that place memory is precisely maintained for 28 days, although the recall of place memory shifts from hippocampus-dependent to hippocampus-independent with time. Moreover, the inactivation of the hippocampal function does not inhibit the precision of remote place memory. Conclusion: These results indicate that the quality of place memories is not determined by brain regions on which the memory depends. |
| first_indexed | 2024-09-23T12:58:56Z |
| format | Article |
| id | mit-1721.1/69969 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:58:56Z |
| publishDate | 2012 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/699692022-09-28T11:17:54Z Hippocampal function is not required for the precision of remote place memory Kitamura, Takashi Okubo-suzuki, Reiko Takashima, Noriko Murayama, Akiko Hino, Toshiaki Nishizono, Hirofumi Kida, Satoshi Inokuchi, Kaoru Picower Institute for Learning and Memory Kitamura, Takashi Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of original place memories also transforms from a precise form to a less precise form with similar time course. The question arises of whether the quality of original place memories is determined by brain regions on which the memory depends. Results: To directly test this idea, we introduced a new procedure: a non-associative place recognition memory test in mice. Combined with genetic and pharmacological approaches, our analyses revealed that place memory is precisely maintained for 28 days, although the recall of place memory shifts from hippocampus-dependent to hippocampus-independent with time. Moreover, the inactivation of the hippocampal function does not inhibit the precision of remote place memory. Conclusion: These results indicate that the quality of place memories is not determined by brain regions on which the memory depends. Japan. Science and Technology Agency (Core Research for Evolutional Science and Technology (CREST) program) Mitsubishi Foundation Sasagawa Scientific 2012-04-09T13:10:58Z 2012-04-09T13:10:58Z 2012-02 2012-01 2012-04-03T11:05:13Z Article http://purl.org/eprint/type/JournalArticle 1756-6606 http://hdl.handle.net/1721.1/69969 Kitamura, Takashi et al. “Hippocampal function is not required for the precision of remote place memory.” Molecular Brain 5.1 (2012): 5. en http://dx.doi.org/10.1186/1756-6606-5-5 Molecular Brain Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Kitamura et al.; licensee BioMed Central Ltd. application/pdf BioMed Central Ltd BioMed Central Ltd |
| spellingShingle | Kitamura, Takashi Okubo-suzuki, Reiko Takashima, Noriko Murayama, Akiko Hino, Toshiaki Nishizono, Hirofumi Kida, Satoshi Inokuchi, Kaoru Hippocampal function is not required for the precision of remote place memory |
| title | Hippocampal function is not required for the precision of remote place memory |
| title_full | Hippocampal function is not required for the precision of remote place memory |
| title_fullStr | Hippocampal function is not required for the precision of remote place memory |
| title_full_unstemmed | Hippocampal function is not required for the precision of remote place memory |
| title_short | Hippocampal function is not required for the precision of remote place memory |
| title_sort | hippocampal function is not required for the precision of remote place memory |
| url | http://hdl.handle.net/1721.1/69969 |
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