Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate
Placement of deep brain stimulating electrodes in the subthalamic nucleus (STN) to treat Parkinson's disease (PD) also allows the recording of single neuron spiking activity. Analyses of these unique data offer an important opportunity to better understand the pathophysiology of PD. Despite the...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2012
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| Online Access: | http://hdl.handle.net/1721.1/70047 https://orcid.org/0000-0003-2668-7819 |
| _version_ | 1826217314085765120 |
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| author | Sarma, Sridevi V. Eden, Uri T. Cheng, Ming L. Williams, Ziv M. Hu, Rollin Eskandar, Emad Brown, Emery N. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Sarma, Sridevi V. Eden, Uri T. Cheng, Ming L. Williams, Ziv M. Hu, Rollin Eskandar, Emad Brown, Emery N. |
| author_sort | Sarma, Sridevi V. |
| collection | MIT |
| description | Placement of deep brain stimulating electrodes in the subthalamic nucleus (STN) to treat Parkinson's disease (PD) also allows the recording of single neuron spiking activity. Analyses of these unique data offer an important opportunity to better understand the pathophysiology of PD. Despite the point process nature of PD neural spiking activity, point process methods are rarely used to analyze these recordings. We develop a point process representation of PD neural spiking activity using a generalized linear model to describe long- and short-term temporal dependencies in the spiking activity of 28 STN neurons from seven PD patients and 35 neurons from one healthy primate (surrogate control) recorded, while the subjects executed a directed-hand movement task. We used the point process model to characterize each neuron's bursting, oscillatory, and directional tuning properties during key periods in the task trial. Relative to the control neurons, the PD neurons showed increased bursting, increased 10-30 Hz oscillations, and increased fluctuations in directional tuning. These features, which traditional methods failed to capture accurately, were efficiently summarized in a single model in the point process analysis of each neuron. The point process framework suggests a useful approach for developing quantitative neural correlates that may be related directly to the movement and behavioral disorders characteristic of PD. |
| first_indexed | 2024-09-23T17:01:40Z |
| format | Article |
| id | mit-1721.1/70047 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:01:40Z |
| publishDate | 2012 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/700472022-09-29T23:08:53Z Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate Sarma, Sridevi V. Eden, Uri T. Cheng, Ming L. Williams, Ziv M. Hu, Rollin Eskandar, Emad Brown, Emery N. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Brown, Emery N. Sarma, Sridevi V. Brown, Emery N. Eden, Uri T. Placement of deep brain stimulating electrodes in the subthalamic nucleus (STN) to treat Parkinson's disease (PD) also allows the recording of single neuron spiking activity. Analyses of these unique data offer an important opportunity to better understand the pathophysiology of PD. Despite the point process nature of PD neural spiking activity, point process methods are rarely used to analyze these recordings. We develop a point process representation of PD neural spiking activity using a generalized linear model to describe long- and short-term temporal dependencies in the spiking activity of 28 STN neurons from seven PD patients and 35 neurons from one healthy primate (surrogate control) recorded, while the subjects executed a directed-hand movement task. We used the point process model to characterize each neuron's bursting, oscillatory, and directional tuning properties during key periods in the task trial. Relative to the control neurons, the PD neurons showed increased bursting, increased 10-30 Hz oscillations, and increased fluctuations in directional tuning. These features, which traditional methods failed to capture accurately, were efficiently summarized in a single model in the point process analysis of each neuron. The point process framework suggests a useful approach for developing quantitative neural correlates that may be related directly to the movement and behavioral disorders characteristic of PD. Burroughs Wellcome Fund L'Oréal (Firm) (FWIS Fellowship) National Institutes of Health (U.S.) (NIH—National Eye Institute under Grant 1R01EY017658) National Institutes of Health (U.S.) (NIH—National Institute Drug Addiction under Grant 1R01NS063249) National Science Foundation (U.S.) (Grant IOB 0645886) Howard Hughes Medical Institute Esther A. & Joseph Klingenstein Fund National Institutes of Health (U.S.) (Grant R01-DA015644) National Institutes of Health (U.S.) (Grant DP1-OD003646) 2012-04-18T15:46:33Z 2012-04-18T15:46:33Z 2010-06 2009-08 Article http://purl.org/eprint/type/JournalArticle 0018-9294 1558-2531 INSPEC Accession Number: 11340759 http://hdl.handle.net/1721.1/70047 Sarma, Sridevi V. et al. “Using Point Process Models to Compare Neural Spiking Activity in the Subthalamic Nucleus of Parkinson's Patients and a Healthy Primate.” IEEE Transactions on Biomedical Engineering 57.6 (2010): 1297–1305. Web. © 2010 IEEE. 20172804 https://orcid.org/0000-0003-2668-7819 en_US http://dx.doi.org/10.1109/tbme.2009.2039213 IEEE Transactions on Biomedical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers IEEE |
| spellingShingle | Sarma, Sridevi V. Eden, Uri T. Cheng, Ming L. Williams, Ziv M. Hu, Rollin Eskandar, Emad Brown, Emery N. Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate |
| title | Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate |
| title_full | Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate |
| title_fullStr | Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate |
| title_full_unstemmed | Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate |
| title_short | Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate |
| title_sort | using point process models to compare neural spiking activity in the nucleus of parkinson s patients and a healthy primate |
| url | http://hdl.handle.net/1721.1/70047 https://orcid.org/0000-0003-2668-7819 |
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