Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons
A modeling study of hippocampal pyramidal neurons is described. This study is based on simulations using HIPPO, a program which simulates the somatic electrical activity of these cells. HIPPO is based on a) descriptions of eleven non-linear conductances that have been either reported for this...
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| Language: | en_US |
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2004
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| Online Access: | http://hdl.handle.net/1721.1/7023 |
| _version_ | 1826201835154702336 |
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| author | Borg-Graham, Lyle J. |
| author_facet | Borg-Graham, Lyle J. |
| author_sort | Borg-Graham, Lyle J. |
| collection | MIT |
| description | A modeling study of hippocampal pyramidal neurons is described. This study is based on simulations using HIPPO, a program which simulates the somatic electrical activity of these cells. HIPPO is based on a) descriptions of eleven non-linear conductances that have been either reported for this class of cell in the literature or postulated in the present study, and b) an approximation of the electrotonic structure of the cell that is derived in this thesis, based on data for the linear properties of these cells. HIPPO is used a) to integrate empirical data from a variety of sources on the electrical characteristics of this type of cell, b) to investigate the functional significance of the various elements that underly the electrical behavior, and c) to provide a tool for the electrophysiologist to supplement direct observation of these cells and provide a method of testing speculations regarding parameters that are not accessible. |
| first_indexed | 2024-09-23T11:57:38Z |
| id | mit-1721.1/7023 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:57:38Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | mit-1721.1/70232019-04-10T11:52:18Z Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons Borg-Graham, Lyle J. A modeling study of hippocampal pyramidal neurons is described. This study is based on simulations using HIPPO, a program which simulates the somatic electrical activity of these cells. HIPPO is based on a) descriptions of eleven non-linear conductances that have been either reported for this class of cell in the literature or postulated in the present study, and b) an approximation of the electrotonic structure of the cell that is derived in this thesis, based on data for the linear properties of these cells. HIPPO is used a) to integrate empirical data from a variety of sources on the electrical characteristics of this type of cell, b) to investigate the functional significance of the various elements that underly the electrical behavior, and c) to provide a tool for the electrophysiologist to supplement direct observation of these cells and provide a method of testing speculations regarding parameters that are not accessible. 2004-10-20T20:22:35Z 2004-10-20T20:22:35Z 1989-09-01 AITR-1161 http://hdl.handle.net/1721.1/7023 en_US AITR-1161 36745155 bytes 29879792 bytes application/postscript application/pdf application/postscript application/pdf |
| spellingShingle | Borg-Graham, Lyle J. Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons |
| title | Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons |
| title_full | Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons |
| title_fullStr | Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons |
| title_full_unstemmed | Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons |
| title_short | Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons |
| title_sort | modelling the somantic electrical response of hippocampal pyramidal neurons |
| url | http://hdl.handle.net/1721.1/7023 |
| work_keys_str_mv | AT borggrahamlylej modellingthesomanticelectricalresponseofhippocampalpyramidalneurons |