The evolution of metazoan extracellular matrix
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone...
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| Format: | Article |
| Language: | en_US |
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Rockefeller University Press, The
2012
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| Online Access: | http://hdl.handle.net/1721.1/70517 https://orcid.org/0000-0001-7603-8396 |
| _version_ | 1811091101677780992 |
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| author | Hynes, Richard O |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hynes, Richard O |
| author_sort | Hynes, Richard O |
| collection | MIT |
| description | The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa. |
| first_indexed | 2024-09-23T14:57:02Z |
| format | Article |
| id | mit-1721.1/70517 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:57:02Z |
| publishDate | 2012 |
| publisher | Rockefeller University Press, The |
| record_format | dspace |
| spelling | mit-1721.1/705172022-09-29T11:37:31Z The evolution of metazoan extracellular matrix Hynes, Richard O Massachusetts Institute of Technology. Department of Biology Hynes, Richard O. Hynes, Richard O. The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa. Howard Hughes Medical Institute 2012-05-04T21:23:09Z 2012-05-04T21:23:09Z 2012-03 2011-09 Article http://purl.org/eprint/type/JournalArticle 0021-9525 1540-8140 http://hdl.handle.net/1721.1/70517 Hynes, R. O. “Evolution: The Evolution of Metazoan Extracellular Matrix.” The Journal of Cell Biology 196.6 (2012): 671–679. Web. 4 May 2012. https://orcid.org/0000-0001-7603-8396 en_US http://dx.doi.org/10.1083/jcb.201109041 Journal of Cell Biology Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Rockefeller University Press, The Rockefeller UP |
| spellingShingle | Hynes, Richard O The evolution of metazoan extracellular matrix |
| title | The evolution of metazoan extracellular matrix |
| title_full | The evolution of metazoan extracellular matrix |
| title_fullStr | The evolution of metazoan extracellular matrix |
| title_full_unstemmed | The evolution of metazoan extracellular matrix |
| title_short | The evolution of metazoan extracellular matrix |
| title_sort | evolution of metazoan extracellular matrix |
| url | http://hdl.handle.net/1721.1/70517 https://orcid.org/0000-0001-7603-8396 |
| work_keys_str_mv | AT hynesrichardo theevolutionofmetazoanextracellularmatrix AT hynesrichardo evolutionofmetazoanextracellularmatrix |