Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. A...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
IOS Press
2012
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| Online Access: | http://hdl.handle.net/1721.1/70603 https://orcid.org/0000-0003-1158-5692 |
| Summary: | A randomized pilot experiment examined the neural substrates of response to cognitive training in
participants with mild cognitive impairment (MCI). Participants performed exercises previously
demonstrated to improve verbal memory and an active control group performed other computer
activities. An auditory-verbal fMRI task was conducted before and after the two-month training
program. Verbal memory scores improved significantly and left hippocampal activation increased
significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain
sufficient neuroplasticity to benefit from cognitive training. |
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