Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. A...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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IOS Press
2012
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| Online Access: | http://hdl.handle.net/1721.1/70603 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1826215076308189184 |
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| author | Rosen, Allyson C. Sugiura, Lisa Kramer, Joel H. Gabrieli, Susan Gabrieli, John D. E. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Rosen, Allyson C. Sugiura, Lisa Kramer, Joel H. Gabrieli, Susan Gabrieli, John D. E. |
| author_sort | Rosen, Allyson C. |
| collection | MIT |
| description | A randomized pilot experiment examined the neural substrates of response to cognitive training in
participants with mild cognitive impairment (MCI). Participants performed exercises previously
demonstrated to improve verbal memory and an active control group performed other computer
activities. An auditory-verbal fMRI task was conducted before and after the two-month training
program. Verbal memory scores improved significantly and left hippocampal activation increased
significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain
sufficient neuroplasticity to benefit from cognitive training. |
| first_indexed | 2024-09-23T16:16:09Z |
| format | Article |
| id | mit-1721.1/70603 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:16:09Z |
| publishDate | 2012 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | mit-1721.1/706032022-10-02T07:24:20Z Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study Rosen, Allyson C. Sugiura, Lisa Kramer, Joel H. Gabrieli, Susan Gabrieli, John D. E. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gabrieli, John D. E. Gabrieli, Susan Gabrieli, John D. E. A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training. National Institute on Aging (K01AG025157) National Institute on Aging (AG12995) National Institute on Aging (AG09466) National Institute on Aging (AG05865 01) National Institute of Mental Health (U.S.) (MH35182) National Institute of Mental Health (U.S.) (MH59940) National Center for Research Resources (U.S.) (RR09784) Posit Science (Firm) 2012-05-14T20:31:43Z 2012-05-14T20:31:43Z 2011-08 Article http://purl.org/eprint/type/JournalArticle 1875-8908 1387-2877 http://hdl.handle.net/1721.1/70603 Rosen, Allyson C. et al. "Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study." Journal of Alzheimer’s Disease 2011 ; 26(Suppl 3): 349–357. https://orcid.org/0000-0003-1158-5692 en_US http://iospress.metapress.com/content/x083w76454777605/fulltext.pdf Journal of Alzheimer's Disease Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf IOS Press PubMed Central |
| spellingShingle | Rosen, Allyson C. Sugiura, Lisa Kramer, Joel H. Gabrieli, Susan Gabrieli, John D. E. Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study |
| title | Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study |
| title_full | Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study |
| title_fullStr | Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study |
| title_full_unstemmed | Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study |
| title_short | Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study |
| title_sort | cognitive training changes hippocampal function in mild cognitive impairment a pilot study |
| url | http://hdl.handle.net/1721.1/70603 https://orcid.org/0000-0003-1158-5692 |
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