Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters
Supplementary data associated with this article can be found in the online version at doi:10.1016/j.dci.2007. 08.005.
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Online Access: | http://hdl.handle.net/1721.1/70959 https://orcid.org/0000-0003-0570-355X |
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author | Zimmerman, Anastasia M. Yeo, Gene Howe, Kerstin Maddox, Benjamin J. Steiner, Lisa A. |
author2 | Massachusetts Institute of Technology. Department of Biology |
author_facet | Massachusetts Institute of Technology. Department of Biology Zimmerman, Anastasia M. Yeo, Gene Howe, Kerstin Maddox, Benjamin J. Steiner, Lisa A. |
author_sort | Zimmerman, Anastasia M. |
collection | MIT |
description | Supplementary data associated with this article can be
found in the online version at doi:10.1016/j.dci.2007.
08.005. |
first_indexed | 2024-09-23T14:23:10Z |
format | Article |
id | mit-1721.1/70959 |
institution | Massachusetts Institute of Technology |
language | en_US |
last_indexed | 2024-09-23T14:23:10Z |
publishDate | 2012 |
publisher | Elsevier |
record_format | dspace |
spelling | mit-1721.1/709592022-10-01T20:59:37Z Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (VL–JL–CL) gene clusters Zimmerman, Anastasia M. Yeo, Gene Howe, Kerstin Maddox, Benjamin J. Steiner, Lisa A. Massachusetts Institute of Technology. Department of Biology Steiner, Lisa A. Burns, Anastasia M. Steiner, Lisa A. Supplementary data associated with this article can be found in the online version at doi:10.1016/j.dci.2007. 08.005. In mammals, Immunoglobulin light chain (IgL) are localized to two chromosomal regions (designated κ and λ). Here we report a genome-wide survey of IgL genes in the zebrafish revealing (V[subscript L]–J[subscript L]–C[subscript L]) clusters spanning 5 separate chromosomes. To elucidate IgL loci present in the zebrafish genome assembly (Zv6), conventional sequence similarity searches and a novel scanning approach based on recombination signal sequence (RSS) motifs were applied. RT-PCR with zebrafish cDNA was used to confirm annotations, evaluate VJ-rearrangement possibilities and show that each chromosomal locus is expressed. In contrast to other vertebrates in which IgL exon usage has been studied, inversional rearrangement between (V[subscript L]–J[subscript L]–C[subscript L]) clusters were found. Inter-cluster rearrangements may convey a selective advantage for editing self-reactive receptors and poise zebrafish by virtue of their extensive numbers of V[subscript L], J[subscript L] and C[subscript L] to have greater potential for immunoglobulin gene shuffling than traditionally studied mice and human models. 2012-05-25T22:16:43Z 2012-05-25T22:16:43Z 2007-09 2007-07 Article http://purl.org/eprint/type/JournalArticle 0145-305X http://hdl.handle.net/1721.1/70959 Zimmerman, Anastasia M. et al. “Immunoglobulin Light Chain (IgL) Genes in Zebrafish: Genomic Configurations and Inversional Rearrangements Between (VL–JL–CL) Gene Clusters.” Developmental & Comparative Immunology 32.4 (2008): 421–434. Web. 25 May 2012. © 2007 Elsevier Inc. https://orcid.org/0000-0003-0570-355X en_US http://dx.doi.org/10.1016/j.dci.2007.08.005 Developmental and Comparative Immunology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
spellingShingle | Zimmerman, Anastasia M. Yeo, Gene Howe, Kerstin Maddox, Benjamin J. Steiner, Lisa A. Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters |
title | Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters |
title_full | Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters |
title_fullStr | Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters |
title_full_unstemmed | Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters |
title_short | Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters |
title_sort | immunoglobulin light chain igl genes in zebrafish genomic configurations and inversional rearrangements between v subscript l j subscript l c subscript l gene clusters |
url | http://hdl.handle.net/1721.1/70959 https://orcid.org/0000-0003-0570-355X |
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