Towards a carbon nanotube antibody sensor
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, February 2012.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2012
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| Online Access: | http://hdl.handle.net/1721.1/71463 |
| _version_ | 1826198433373880320 |
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| author | Bojö, Peter |
| author2 | Michael Strano. |
| author_facet | Michael Strano. Bojö, Peter |
| author_sort | Bojö, Peter |
| collection | MIT |
| description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, February 2012. |
| first_indexed | 2024-09-23T11:04:53Z |
| format | Thesis |
| id | mit-1721.1/71463 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:04:53Z |
| publishDate | 2012 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/714632019-04-12T15:42:48Z Towards a carbon nanotube antibody sensor Bojö, Peter Michael Strano. Massachusetts Institute of Technology. Dept. of Biological Engineering. Massachusetts Institute of Technology. Dept. of Biological Engineering. Biological Engineering. Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, February 2012. Cataloged from PDF version of thesis. Includes bibliographical references (p. 46-51). This work investigated single-walled carbon nanotube (SWNT)/polymer-protein A complexes for optically reporting antibody concentration via a change in near infrared fluorescent emission after antibody binding. SWNT have potential as biosensors because of extraordinary sensitivity, lack of photobleaching, and optical activity in a near-infrared window. A SWNT sensor could provide label-free measurements of antibody concentration in a continuous fashion, which may aid selection of production strains. Protein A itself, dextran, poly vinyl alcohol, DNA sequences, and chitosan were used as polymers for wrapping SWNT. Nonspecific binding to solution-phase constructs was found to be a major problem with these approaches. Chitosan hydrogels encapsulating SWNT also show nonspecific responses. by Peter Bojö. M.Eng. 2012-07-02T15:43:14Z 2012-07-02T15:43:14Z 2011 2012 Thesis http://hdl.handle.net/1721.1/71463 795184338 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 51 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biological Engineering. Bojö, Peter Towards a carbon nanotube antibody sensor |
| title | Towards a carbon nanotube antibody sensor |
| title_full | Towards a carbon nanotube antibody sensor |
| title_fullStr | Towards a carbon nanotube antibody sensor |
| title_full_unstemmed | Towards a carbon nanotube antibody sensor |
| title_short | Towards a carbon nanotube antibody sensor |
| title_sort | towards a carbon nanotube antibody sensor |
| topic | Biological Engineering. |
| url | http://hdl.handle.net/1721.1/71463 |
| work_keys_str_mv | AT bojopeter towardsacarbonnanotubeantibodysensor |