Macromolecular Crowding Directs Extracellular Matrix Organization and Mesenchymal Stem Cell Behavior

Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture. Here, we induced macromolecular crowding in vitro by using synthetic macromolecular globules of nm-scale radius at phy...

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Bibliographic Details
Main Authors: Zeiger, Adam Scott, Loe, Felicia C., Li, Ran, Raghunath, Michael, Van Vliet, Krystyn J. Van
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2012
Online Access:http://hdl.handle.net/1721.1/71642
https://orcid.org/0000-0001-5735-0560
https://orcid.org/0000-0002-8537-8824