2′-O Methylation of Internal Adenosine by Flavivirus NS[subscript 5] Methyltransferase

2′-O Methylation of Internal Adenosine by Flavivirus NS[subscript 5] Methyltransferase

RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2′-O methyltransferase activities that are required for the formation of 5′ type I cap (m[superscript 7]GpppAm) of viral RNA genome. Here we reported, for the first time, that fla...

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Bibliographic Details
Main Authors: Dong, Hongping, Chang, David C., Ho, Chia-Hua, Lim, Siew Pheng, Chionh, Yok Hian, Hia, Fabian, Lee, Yie Hou, Kukkaro, Petra, Lok, Shee-Mei, Dedon, Peter C., Shi, Pei-Yong
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2012
Online Access:http://hdl.handle.net/1721.1/71754
https://orcid.org/0000-0003-0011-3067

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