Rapid translocation of nanoparticles from the lung airspaces to the body
Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and th...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/71921 https://orcid.org/0000-0003-2220-4365 |
| _version_ | 1811079681332477952 |
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| author | Choi, Hak Soo Ashitate, Yoshitomo Lee, Jeong Heon Kim, Soon Hee Matsui, Aya Insin, Numpon Bawendi, Moungi G. Semmler-Behnke, Manuela Frangioni, John V. Tsuda, Akira |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Choi, Hak Soo Ashitate, Yoshitomo Lee, Jeong Heon Kim, Soon Hee Matsui, Aya Insin, Numpon Bawendi, Moungi G. Semmler-Behnke, Manuela Frangioni, John V. Tsuda, Akira |
| author_sort | Choi, Hak Soo |
| collection | MIT |
| description | Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes. Nanoparticles of HD < 6 nm can traffic rapidly from the lungs to lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys. We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis. |
| first_indexed | 2024-09-23T11:18:58Z |
| format | Article |
| id | mit-1721.1/71921 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:18:58Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/719212022-10-01T02:43:26Z Rapid translocation of nanoparticles from the lung airspaces to the body Choi, Hak Soo Ashitate, Yoshitomo Lee, Jeong Heon Kim, Soon Hee Matsui, Aya Insin, Numpon Bawendi, Moungi G. Semmler-Behnke, Manuela Frangioni, John V. Tsuda, Akira Massachusetts Institute of Technology. Department of Chemistry Bawendi, Moungi G. Insin, Numpon Bawendi, Moungi G. Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes. Nanoparticles of HD < 6 nm can traffic rapidly from the lungs to lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys. We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis. 2012-07-31T18:22:37Z 2012-07-31T18:22:37Z 2010-11 2010-04 Article http://purl.org/eprint/type/JournalArticle 1087-0156 1546-1696 http://hdl.handle.net/1721.1/71921 Choi, Hak Soo et al. “Rapid Translocation of Nanoparticles from the Lung Airspaces to the Body.” Nature Biotechnology 28.12 (2010): 1300–1303. https://orcid.org/0000-0003-2220-4365 en_US http://dx.doi.org/10.1038/nbt.1696 Nature Biotechnology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Choi, Hak Soo Ashitate, Yoshitomo Lee, Jeong Heon Kim, Soon Hee Matsui, Aya Insin, Numpon Bawendi, Moungi G. Semmler-Behnke, Manuela Frangioni, John V. Tsuda, Akira Rapid translocation of nanoparticles from the lung airspaces to the body |
| title | Rapid translocation of nanoparticles from the lung airspaces to the body |
| title_full | Rapid translocation of nanoparticles from the lung airspaces to the body |
| title_fullStr | Rapid translocation of nanoparticles from the lung airspaces to the body |
| title_full_unstemmed | Rapid translocation of nanoparticles from the lung airspaces to the body |
| title_short | Rapid translocation of nanoparticles from the lung airspaces to the body |
| title_sort | rapid translocation of nanoparticles from the lung airspaces to the body |
| url | http://hdl.handle.net/1721.1/71921 https://orcid.org/0000-0003-2220-4365 |
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