Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes
Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable met...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/71922 https://orcid.org/0000-0001-7215-1439 |
| _version_ | 1811097064735506432 |
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| author | Song, Yong-Ak Melik, Rohat Rabie, Amr N. Ibrahim, Ahmed M. S. Moses, David Tan, Ara Han, Jongyoon Lin, Samuel J. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Song, Yong-Ak Melik, Rohat Rabie, Amr N. Ibrahim, Ahmed M. S. Moses, David Tan, Ara Han, Jongyoon Lin, Samuel J. |
| author_sort | Song, Yong-Ak |
| collection | MIT |
| description | Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations in situ along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes. |
| first_indexed | 2024-09-23T16:53:46Z |
| format | Article |
| id | mit-1721.1/71922 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:53:46Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/719222022-09-29T22:12:54Z Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes Song, Yong-Ak Melik, Rohat Rabie, Amr N. Ibrahim, Ahmed M. S. Moses, David Tan, Ara Han, Jongyoon Lin, Samuel J. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Han, Jongyoon Song, Yong-Ak Melik, Rohat Han, Jongyoon Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations in situ along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes. Massachusetts Institute of Technology. Faculty Discretionary Research Fund National Institutes of Health (U.S.) (Award UL1 RR 025758) Harvard Catalyst (Grant) 2012-07-31T19:16:41Z 2012-07-31T19:16:41Z 2011-10 2010-12 Article http://purl.org/eprint/type/JournalArticle 1476-1122 1476-4660 http://hdl.handle.net/1721.1/71922 Song, Yong-Ak et al. “Electrochemical Activation and Inhibition of Neuromuscular Systems Through Modulation of Ion Concentrations with Ion-selective Membranes.” Nature Materials 10.12 (2011): 980–986. https://orcid.org/0000-0001-7215-1439 en_US http://dx.doi.org/10.1038/nmat3146 Nature Materials Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group PubMed Central |
| spellingShingle | Song, Yong-Ak Melik, Rohat Rabie, Amr N. Ibrahim, Ahmed M. S. Moses, David Tan, Ara Han, Jongyoon Lin, Samuel J. Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
| title | Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
| title_full | Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
| title_fullStr | Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
| title_full_unstemmed | Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
| title_short | Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
| title_sort | electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion selective membranes |
| url | http://hdl.handle.net/1721.1/71922 https://orcid.org/0000-0001-7215-1439 |
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