Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors
Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation, signaling, and translocation of these two species has emerged in several areas of human physiology, p...
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| Format: | Article |
| Language: | en_US |
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Annual Reviews
2012
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| Online Access: | http://hdl.handle.net/1721.1/71928 https://orcid.org/0000-0002-2693-4982 |
| _version_ | 1811085932624871424 |
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| author | Pluth, Michael D. Tomat, Elisa Lippard, Stephen J. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Pluth, Michael D. Tomat, Elisa Lippard, Stephen J. |
| author_sort | Pluth, Michael D. |
| collection | MIT |
| description | Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation, signaling, and translocation of these two species has emerged in several areas of human physiology, providing additional incentive for developing adequate detection systems for Zn(II) ions and NO in biological specimens. Fluorescent probes for both of these bioinorganic analytes provide excellent tools for their detection, with high spatial and temporal resolution. We review the most widely used fluorescent sensors for biological zinc and nitric oxide, together with promising new developments and unmet needs of contemporary Zn(II) and NO biological imaging. The interplay between zinc and nitric oxide in the nervous, cardiovascular, and immune systems is highlighted to illustrate the contributions of selective fluorescent probes to the study of these two important bioinorganic analytes. |
| first_indexed | 2024-09-23T13:17:43Z |
| format | Article |
| id | mit-1721.1/71928 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:17:43Z |
| publishDate | 2012 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | mit-1721.1/719282022-10-01T14:19:51Z Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors Pluth, Michael D. Tomat, Elisa Lippard, Stephen J. Massachusetts Institute of Technology. Department of Chemistry Lippard, Stephen J. Pluth, Michael D. Tomat, Elisa Lippard, Stephen J. Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation, signaling, and translocation of these two species has emerged in several areas of human physiology, providing additional incentive for developing adequate detection systems for Zn(II) ions and NO in biological specimens. Fluorescent probes for both of these bioinorganic analytes provide excellent tools for their detection, with high spatial and temporal resolution. We review the most widely used fluorescent sensors for biological zinc and nitric oxide, together with promising new developments and unmet needs of contemporary Zn(II) and NO biological imaging. The interplay between zinc and nitric oxide in the nervous, cardiovascular, and immune systems is highlighted to illustrate the contributions of selective fluorescent probes to the study of these two important bioinorganic analytes. National Science Foundation (Grant Number CHE-0907905) National Institutes of Health (U.S.) (Grant Number GM065519) National Institutes of Health (U.S.) (Grant Number K99GM092970) 2012-07-31T20:44:42Z 2012-07-31T20:44:42Z 2011-07 Article http://purl.org/eprint/type/JournalArticle 0066-4154 0066-4154 http://hdl.handle.net/1721.1/71928 Pluth, Michael D., Elisa Tomat, and Stephen J. Lippard. “Biochemistry of Mobile Zinc and Nitric Oxide Revealed by Fluorescent Sensors.” Annual Review of Biochemistry 80.1 (2011): 333–355. https://orcid.org/0000-0002-2693-4982 en_US http://dx.doi.org/10.1146/annurev-biochem-061009-091643 Annual Review of Biochemistry Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Annual Reviews PMC |
| spellingShingle | Pluth, Michael D. Tomat, Elisa Lippard, Stephen J. Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| title | Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| title_full | Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| title_fullStr | Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| title_full_unstemmed | Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| title_short | Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| title_sort | biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors |
| url | http://hdl.handle.net/1721.1/71928 https://orcid.org/0000-0002-2693-4982 |
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