Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization
The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The generality of these simple and efficient procedures is demonstrated through the synthesis of a wide variet...
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| Format: | Article |
| Language: | en_US |
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Organic Letters
2012
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| Online Access: | http://hdl.handle.net/1721.1/71942 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1826214517576564736 |
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| author | Henderson, Jaclyn L. Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Henderson, Jaclyn L. Buchwald, Stephen Leffler |
| author_sort | Henderson, Jaclyn L. |
| collection | MIT |
| description | The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The generality of these simple and efficient procedures is demonstrated through the synthesis of a wide variety of structural types. |
| first_indexed | 2024-09-23T16:07:01Z |
| format | Article |
| id | mit-1721.1/71942 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:07:01Z |
| publishDate | 2012 |
| publisher | Organic Letters |
| record_format | dspace |
| spelling | mit-1721.1/719422022-09-29T18:18:20Z Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization Henderson, Jaclyn L. Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Buchwald, Stephen L. Henderson, Jaclyn L. Buchwald, Stephen Leffler The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The generality of these simple and efficient procedures is demonstrated through the synthesis of a wide variety of structural types. Amgen, Inc. National Institutes of Health (U.S.) (Grant Number GM-58160) 2012-08-01T19:22:05Z 2012-08-01T19:22:05Z 2010-09 2010-08 Article http://purl.org/eprint/type/JournalArticle 1523-7060 1523-7052 http://hdl.handle.net/1721.1/71942 Henderson, Jaclyn L., and Stephen L. Buchwald. “Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization.” Organic Letters 12.20 (2010): 4442–4445. https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1021/ol101929v American Chemical Society (ACS) Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Organic Letters PMC |
| spellingShingle | Henderson, Jaclyn L. Buchwald, Stephen Leffler Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization |
| title | Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization |
| title_full | Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization |
| title_fullStr | Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization |
| title_full_unstemmed | Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization |
| title_short | Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization |
| title_sort | efficient pd catalyzed amination reactions for heterocycle functionalization |
| url | http://hdl.handle.net/1721.1/71942 https://orcid.org/0000-0003-3875-4775 |
| work_keys_str_mv | AT hendersonjaclynl efficientpdcatalyzedaminationreactionsforheterocyclefunctionalization AT buchwaldstephenleffler efficientpdcatalyzedaminationreactionsforheterocyclefunctionalization |