Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin
We report the observation of liquid-liquid phase separation in a solution of human monoclonal antibody, IgG2, and the effects of human serum albumin, a major blood protein, on this phase separation. We find a significant reduction of phase separation temperature in the presence of albumin, and a pre...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences
2012
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| Online Access: | http://hdl.handle.net/1721.1/72107 https://orcid.org/0000-0003-2414-524X https://orcid.org/0000-0001-6684-7608 |