Using protein design algorithms to understand the molecular basis of disease caused by protein–DNA interactions: the Pax6 example

Using protein design algorithms to understand the molecular basis of disease caused by protein–DNA interactions: the Pax6 example

Quite often a single or a combination of protein mutations is linked to specific diseases. However, distinguishing from sequence information which mutations have real effects in the protein’s function is not trivial. Protein design tools are commonly used to explain mutations that affect protein sta...

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Bibliographic Details
Main Authors: Alibes, Andreu, Nadra, Alejandro D., De Masi, Federico, Bulyk, Martha L., Serrano, Luis, Stricher, Francois
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Oxford University Press 2012
Online Access:http://hdl.handle.net/1721.1/72332

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