An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud

An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud

To elucidate the transcriptional regulation of Bmp4 expression during organogenesis, we used phylogenetic footprinting and transgenic reporter analyses to identify Bmp4 cis-regulatory modules (CRMs). These analyses identified a regulatory region located ~46 kb upstream of the mouse Bmp4 transcriptio...

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Bibliographic Details
Main Authors: Jumlongras, Dolrudee, Lachke, Salil A., O’Connell, Daniel J., Aboukhalil, Anton, Li, Xiao, Choe, Sung E., Ho, Joshua W. K., Turbe-Doan, Annick, Robertson, Erin A., Olsen, Bjorn R., Bulyk, Martha L., Amendt, Brad A., Maas, Richard L.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Public Library of Science 2012
Online Access:http://hdl.handle.net/1721.1/72429

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